Smad7 - SMAD family member 7 Gene

Also Known as Madh7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81516

Summary

Enables ubiquitin protein Ligase binding activity. Involved in intracellular signal transduction; negative regulation of transcription, DNA-templated; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in several cellular components, including centrosome; cytosol; and nuclear lumen. Predicted to be part of heteromeric SMAD protein complex. Predicted to colocalize with adherens junction. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in colorectal Cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (Smad Family member 7). [provided by Alliance of Genome Resources, Apr 2022]

Smad7 Products (1)

mRNA Protein Name
NM_030858.2 NP_110485.1 mothers against decapentaplegic homolog 7

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18762808 RGD
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
17347560 RGD
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
11959632 RGD
involved in negative regulation of DNA-templated transcription IEP
IEP: Inferred from expression pattern
11959632 RGD
involved in regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
11959632 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 7

  • MAD (mothers against decapentaplegic, Drosophila) homolog 7

  • MAD homolog 7

  • SMAD 7

  • mothers against DPP homolog 7

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0439 Asiaticoside 99.67% Phase 3
HY-145721 Mongersen Inhibitor 98.57% Phase 3

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145721A Mongersen sodium 99.61% Unkown
HY-107802 Breviscapine 99.13% Unkown
HY-170791 CIB-L43 99.71% Unkown
HY-120268A SLM6031434 hydrochloride Inhibitor 99.1% Unkown
HY-RS13398 SMAD7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120268 SLM6031434 Inhibitor / Unkown
HY-175662 TGF-β/Smad-IN-2 Inhibitor / Unkown
HY-N2595 Oxoglaucine / Unkown
HY-N13208 Stevia Powder / Unkown
HY-RS18408 Smad7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24889 Smad7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad7 NCBI NCBI:4092