RND2 - Rho family GTPase 2 Gene

Also Known as ARHN; RHO7; RhoN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8153

About RND2

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,025,231-43,032,041 (from NCBI)

This gene has 2 transcripts (splice variants), 263 orthologues and 22 paralogues. Biased expression in brain (RPKM 14.7), testis (RPKM 13.8) and 5 other tissues.

Summary

This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin Cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian Cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]

RND2 Products (1)

mRNA Protein Name
NM_005440.5 NP_005431.1 rho-related GTP-binding protein RhoN

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12590651 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RND2 Protein Structure

Ras

Ras: Ras family (9 - 176)

  • 0
  • 100
  • 200
  • 227 a.a.
Protein Preferred Names Protein Names

rho-related GTP-binding protein RhoN

  • CTD-3199J23.4

RND2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RND2 P52198 PLXNB1 Homo sapiens O43157
GMS
29040270
Intra
RND2 P52198 PLXNB1 Homo sapiens O43157
ITC
29040270
Intra
RND2 P52198 USP47 Homo sapiens Q96K76
Anti Tag CoIP
33961781
Intra
RND2 P52198 USP47 Homo sapiens Q96K76
Anti Tag CoIP
28514442
Intra
RND2 P52198 PLXNB2 Homo sapiens O15031
ITC
29040270
Intra
RND2 P52198 PLXNB2 Homo sapiens O15031
GMS
29040270
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ascaridiasis

  • Ascariasis
Toxic Megacolon

  • Megacolon, Toxic

  • Toxic Dilatation Of Colon

  • Toxic Functional Megacolon
Clostridium Difficile Colitis

  • Pseudomembranous Colitis

  • Colitis Pseudomembranous

  • Enterocolitis, Pseudomembranous

  • Pseudomembranous Enterocolitis

  • Clostridium Difficile Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12032 RND2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RND2 VGNC VGNC:64662
Bos taurus RND2 VGNC VGNC:34005
Mus musculus RND2 MGD MGI:1338755
Macaca mulatta RND2 VGNC VGNC:76765
Rattus norvegicus RND2 RGD RGD:1306172
Canis familiaris RND2 VGNC VGNC:45617