USP47 - ubiquitin specific peptidase 47 Gene

Also Known as TRFP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55031

About USP47

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:11,841,972-11,961,887 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 71 paralogues. Ubiquitous expression in brain (RPKM 11.7), heart (RPKM 10.2) and 25 other tissues.

Summary

Enables WD40-repeat domain binding activity and thiol-dependent Deubiquitinase. Involved in several processes, including monoubiquitinated protein deubiquitination; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of nitrogen compound metabolic process. Located in cytoplasm. Part of SCF ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

USP47 Products (16)

mRNA Protein Name
NM_001282659.2 NP_001269588.1 ubiquitin carboxyl-terminal hydrolase 47 isoform a
NM_001330208.2 NP_001317137.1 ubiquitin carboxyl-terminal hydrolase 47 isoform c
NM_001372091.1 NP_001359020.1 ubiquitin carboxyl-terminal hydrolase 47 isoform d
NM_001372092.1 NP_001359021.1 ubiquitin carboxyl-terminal hydrolase 47 isoform e
NM_001372093.1 NP_001359022.1 ubiquitin carboxyl-terminal hydrolase 47 isoform f
NM_001372094.1 NP_001359023.1 ubiquitin carboxyl-terminal hydrolase 47 isoform f
NM_001372095.1 NP_001359024.1 ubiquitin carboxyl-terminal hydrolase 47 isoform g
NM_001372096.1 NP_001359025.1 ubiquitin carboxyl-terminal hydrolase 47 isoform h
NM_001372097.1 NP_001359026.1 ubiquitin carboxyl-terminal hydrolase 47 isoform i
NM_001372098.1 NP_001359027.1 ubiquitin carboxyl-terminal hydrolase 47 isoform j
NM_001372099.1 NP_001359028.1 ubiquitin carboxyl-terminal hydrolase 47 isoform k
NM_001372100.1 NP_001359029.1 ubiquitin carboxyl-terminal hydrolase 47 isoform l
NM_001372101.1 NP_001359030.1 ubiquitin carboxyl-terminal hydrolase 47 isoform n
NM_001372102.1 NP_001359031.1 ubiquitin carboxyl-terminal hydrolase 47 isoform o
NM_001372103.1 NP_001359032.1 ubiquitin carboxyl-terminal hydrolase 47 isoform m
NM_017944.4 NP_060414.3 ubiquitin carboxyl-terminal hydrolase 47 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables WD40-repeat domain binding IPI
IPI: Inferred from physical interaction
19966869 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
21362556 GOA
enables deubiquitinase activity IDA
IDA: Inferred from direct assay
26169834 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21362556 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
21362556 GOA
involved in base-excision repair IMP
IMP: Inferred from mutant phenotype
21362556 GOA
involved in monoubiquitinated protein deubiquitination IDA
IDA: Inferred from direct assay
21362556 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19966869 GOA
involved in negative regulation of G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
19966869 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19966869 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
19966869 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
26169834 GOA
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
19966869 GOA
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
19966869 GOA
Cellular Component GO Annotation Evidence References Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
19966869 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21362556 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
36749823 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP47 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (187 - 561)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1375 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 47

  • Trf (TATA binding protein-related factor)-proximal homolog

USP47 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USP47 Q96K76 AP4M1 Homo sapiens O00189
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13865 P 22077 Inhibitor 98.42% Unkown
HY-112937 GNE-6640 Inhibitor 99.91% Unkown
HY-134817 USP7-IN-8 Inhibitor 99.04% Unkown
HY-13487 USP7/USP47 inhibitor Inhibitor 98.58% Unkown
HY-RS15558 USP47 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174301 USP7-IN-18 / Unkown
HY-111166 USP7/USP47 inhibitor 1 Inhibitor / Unkown
HY-RS17715 Usp47 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24180 Usp47 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USP47 RGD RGD:1310411
Bos taurus USP47 VGNC VGNC:36732
Felis catus USP47 VGNC VGNC:66890
Mus musculus USP47 MGD MGI:1922246
Macaca mulatta USP47 VGNC VGNC:79230
Canis familiaris USP47 VGNC VGNC:48198
Others USP47 NCBI