2. Gene
  3. USP47 - ubiquitin specific peptidase 47 Gene

USP47 - ubiquitin specific peptidase 47 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as TRFP

Gene ID: 55031 | Gene type: protein coding

About USP47

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:11,841,972-11,961,887 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 71 paralogues. Ubiquitous expression in brain (RPKM 11.7), heart (RPKM 10.2) and 25 other tissues.

Summary

Enables WD40-repeat domain binding activity and thiol-dependent Deubiquitinase. Involved in several processes, including monoubiquitinated protein deubiquitination; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of nitrogen compound metabolic process. Located in cytoplasm. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

USP47 Products(16)

mRNA Protein Name
NM_001282659.2 NP_001269588.1 ubiquitin carboxyl-terminal hydrolase 47 isoform a
NM_001330208.2 NP_001317137.1 ubiquitin carboxyl-terminal hydrolase 47 isoform c
NM_001372091.1 NP_001359020.1 ubiquitin carboxyl-terminal hydrolase 47 isoform d
NM_001372092.1 NP_001359021.1 ubiquitin carboxyl-terminal hydrolase 47 isoform e
NM_001372093.1 NP_001359022.1 ubiquitin carboxyl-terminal hydrolase 47 isoform f
NM_001372094.1 NP_001359023.1 ubiquitin carboxyl-terminal hydrolase 47 isoform f
NM_001372095.1 NP_001359024.1 ubiquitin carboxyl-terminal hydrolase 47 isoform g
NM_001372096.1 NP_001359025.1 ubiquitin carboxyl-terminal hydrolase 47 isoform h
NM_001372097.1 NP_001359026.1 ubiquitin carboxyl-terminal hydrolase 47 isoform i
NM_001372098.1 NP_001359027.1 ubiquitin carboxyl-terminal hydrolase 47 isoform j
NM_001372099.1 NP_001359028.1 ubiquitin carboxyl-terminal hydrolase 47 isoform k
NM_001372100.1 NP_001359029.1 ubiquitin carboxyl-terminal hydrolase 47 isoform l
NM_001372101.1 NP_001359030.1 ubiquitin carboxyl-terminal hydrolase 47 isoform n
NM_001372102.1 NP_001359031.1 ubiquitin carboxyl-terminal hydrolase 47 isoform o
NM_001372103.1 NP_001359032.1 ubiquitin carboxyl-terminal hydrolase 47 isoform m
NM_017944.4 NP_060414.3 ubiquitin carboxyl-terminal hydrolase 47 isoform b

USP47 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (187 - 561)

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  • 1375 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 47

Trf (TATA binding protein-related factor)-proximal homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13865 P 22077 Inhibitor 98.44% Unkown
HY-13487 USP7/USP47 inhibitor Inhibitor 98.63% Unkown
HY-134817 USP7-IN-8 Inhibitor 98.80% Unkown
HY-RS15558 USP47 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USP47 RGD RGD:1310411
Bos taurus USP47 VGNC VGNC:36732
Felis catus USP47 VGNC VGNC:66890
Mus musculus USP47 MGD MGI:1922246
Macaca mulatta USP47 VGNC VGNC:79230
Canis familiaris USP47 VGNC VGNC:48198
Others USP47 NCBI