AMN - amnion associated transmembrane protein Gene

Also Known as IGS2; PRO1028; amnionless

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81693

About AMN

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:102,922,663-102,930,842 (from NCBI)

This gene has 7 transcripts (splice variants), 163 orthologues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 39.0), small intestine (RPKM 30.0) and 4 other tissues.

Summary

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]

AMN Products (1)

mRNA	Protein	Name
NM_030943.4	NP_112205.2	protein amnionless precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cargo receptor activity	IDA IDA: Inferred from direct assay	14576052	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	30523278	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	14576052	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi to plasma membrane protein transport	IDA IDA: Inferred from direct assay	14576052	GOA
involved in cobalamin metabolic process	IDA IDA: Inferred from direct assay	14576052	GOA
involved in cobalamin transport	IDA IDA: Inferred from direct assay	14576052	GOA
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	14576052	GOA
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	20088845	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	14576052	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	14576052	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	14576052	GOA
located in membrane	IDA IDA: Inferred from direct assay	14576052	GOA
is active in microvillus membrane	IDA IDA: Inferred from direct assay	14576052	GOA
part of receptor complex	IPI IPI: Inferred from physical interaction	30523278	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMN Protein Structure

Amnionless

0
100
200
300
400
453 a.a.

Protein Preferred Names	Protein Names
protein amnionless	amnionless homolog

AMN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AMN	Q9BXJ7	CUBN	Homo sapiens	O60494	Pull Down	30523278
Intra	AMN	Q9BXJ7	CUBN	Homo sapiens	O60494	Anti Tag CoIP	30523278
Intra	AMN	Q9BXJ7	CUBN	Homo sapiens	O60494	X-Ray Diffraction	30523278

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Imerslund-Grasbeck Syndrome 2	IGS2 Megaloblastic Anemia, Norwegian Type Imerslund-Grasbeck Syndrome Type 2
Megaloblastic Anemia	Imerslund-Grasbeck Syndrome Igs Defect Of Enterocyte Intrinsic Factor Receptor Enterocyte Cobalamin Malabsorption Familial Megaloblastic Anemia Megaloblastic Anemia 1 Selective Cobalamin Malabsorption With Proteinuria Imerslund-Gräsbeck Syndrome Anemia, Megaloblastic Grasbeck-Imerslund Syndrome Megaloblastic Anaemia Mga1 Norwegian Type Recessive Hereditary Megaloblastic Anaemia 1 Recessive Hereditary Megaloblastic Anemia 1 Rh-Mga1 Gräsbeck-Imerslund Disease Pernicious Anemia, Juvenile, Due To Selective Intestinal Malabsorption Of Vitamin B12, With Proteinuria Juvenile Pernicious Anemia With Proteinuria Due To Selective Intestinal Malabsorption Of Vitamin B12 Anemia Megaloblastic Megaloblastic Anemia Due To Inborn Errors Of Metabolism 3-@Methylglutaconic Aciduria, Type I
Vitamin B12 Deficiency	Cobalamin Deficiency Hypocobalaminemia Vitamin B 12 Deficiency Cyanocobalamin Deficiency Deficiency Of Vitamin B12
Imerslund-Grasbeck Syndrome 1	Pernicious Anemia, Juvenile, Due To Selective Intestinal Malabsorption Of Vitamin B12, With Proteinuria IGS1 Megaloblastic Anemia, Finnish Type Mga1 Enterocyte Cobalamin Malabsorption Imerslund-Grasbeck Syndrome Type 1 Megaloblastic Anemia, 1 Enterocyte Intrinsic Factor Receptor, Defect Of Defect Of Enterocyte Intrinsic Factor Receptor Megaloblastic Anemia 1
Congenital Intrinsic Factor Deficiency	Hereditary Intrinsic Factor Deficiency Intrinsic Factor Deficiency Congenital Pernicious Anemia Gastric Intrinsic Factor Deficiency Hereditary Juvenile Megaloblastic Anemia Due To Intrinsic Factor Deficiency Ifd Intrinsic Factor Deficiency, Congenital, Susceptibility To Congenital Deficiency Of Intrinsic Factor Megaloblastic Anemia Due To Inborn Errors Of Metabolism
Donnai-Barrow Syndrome	Faciooculoacousticorenal Syndrome Dbs/Foar Syndrome Foar Syndrome Diaphragmatic Hernia-Exomphalos-Hypertelorism Syndrome Facio-Oculo-Acoustico-Renal Syndrome Diaphragmatic Hernia, Exomphalos, Absent Corpus Callosum, Hypertelorism, Myopia, Sensorineural Deafness, And Proteinuria Diaphragmatic Hernia-Hypertelorism-Myopia-Deafness Syndrome Holmes-Schepens Syndrome Syndrome Of Ocular And Facial Anomalies, Telecanthus And Deafness DBS Diaphragmatic Hernia Exomphalos Absent Corpus Callosum Hypertelorism Myopia Sensorineural Deafness And Proteinuria Diaphragmatic Hernia-Exomphalos-Corpus Callosum Agenesis Diaphragmatic Hernia-Hypertelorism-Myopia-Hearing Loss Syndrome Syndrome Of Ocular And Facial Anomalies, Telecanthus And Hearing Loss Donnai Barrow Syndrome
Tropical Sprue	Tropical Steatorrhea Tropical Enteropathy Sprue, Tropical Sprue - Tropical Idiopathic Tropical Malabsorption Syndrome Tropical Steatorrhoea Tropical Diarrhoea Ts - [Tropical Sprue] Psilosis Sprue Nos
Vitamin Metabolic Disorder
Dent Disease 1	Dent Disease Dent'S Disease Dent Disease 2 Dent Disease Type 1 DENT1 Urolithiasis, Hypercalciuric, X-Linked Nephrolithiasis 2 Nphl2 Dent Syndrome Dents Disease Low-Molecular-Weight Proteinuria With Hypercalciuria And Nephrocalcinosis Renal Fanconi Syndrome With Nephrocalcinosis And Renal Stones X-Linked Recessive Hypercalciuric Hypophosphatemic Rickets X-Linked Recessive Nephrolithiasis Fanconi Syndrome, Renal, With Nephrocalcinosis And Renal Stones Nephrolithiasis, Hypercalciuric, X-Linked Nephrolithiasis-Hypercalciuria X-Linked Recessive Nephrolithiasis, X-Linked Recessive Dent Disease, Type 1
Macrocytic Anemia	Anemia Macrocytic Anemia, Macrocytic Macrocytic Anaemia
Hypercholesterolemia, Familial, 4	Hypercholesterolemia, Autosomal Recessive Arh FHCL4 Autosomal Recessive Hypercholesterolemia Arh1 Arh2 Autosomal Recessive Hypercholesterolemia 1 Autosomal Recessive Hypercholesterolemia 2 Fhcb1 Fhcb2 Hypercholesterolemia, Autosomal Recessive, 1, Formerly Arh1, Formerly Fhcb1, Formerly Hypercholesterolemia, Autosomal Recessive, 2, Formerly Arh2, Formerly Fhcb2, Formerly Familial Autosomal Recessive Hypercholesterolemia Hypercholesterolemia, Familial, Autosomal Recessive Hypercholesterolemia, Familial, Type 4
Pernicious Anemia	Anemia, Pernicious Anemia Pernicious Pernicious Anaemia Addison'S Anaemia Biermer'S Anaemia Biermer'S Anemia Acquired Pernicious Anemia Addison-Biermer Anemia Addisonian Anemia Biermer Anemia Biermer'S Disease Juvenile Onset Pernicious Anemia Biermer Disease Biermer-Addison Disease
Glossitis	Inflammation Of Tongue Tongue Inflammation Glazed Tongue
Methylmalonic Acidemia	Methylmalonic Aciduria Mma Acidemia, Methylmalonic Isolated Methylmalonic Acidemia
Fanconi Syndrome	Infantile Nephropathic Cystinosis Adult Fanconi Syndrome Congenital Fanconi Syndrome De Toni-Fanconi Syndrome Fanconi-De Toni Syndrome Lignac-Fanconi Syndrome Fanconi Renotubular Syndrome Primary Fanconi Renotubular Syndrome De Toni-Debre-Fanconi Syndrome Adult Fanconi Anemia Detoni Fanconi Syndrome Fanconi-De-Toni Syndrome Primary Fanconi Syndrome Detoni-Debre-Fanconi Syndrome Primary Fanconi Renal Syndrome Fanconi Anemia Cystinosis, Infantile Nephropathic Fanconi-Bickel Syndrome Renal Fanconi Syndrome Lowe-Bickel Syndrome
Hypophosphatemic Rickets, X-Linked Recessive	Hypophosphatemic Rickets X-Linked Recessive Hypophosphatemic Rickets XLRHR Hypophosphatemic Rickets Disorders Rickets Hypophosphatemic Rickets, Hypophosphatemic, X-Linked Recessive Familial Hypophosphatemic Rickets

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-10159	Nilotinib	99.94%	Yes
HY-10159A	Nilotinib monohydrochloride monohydrate	99.91%	Yes
HY-10159B	Nilotinib hydrochloride	99.86%	Yes

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103565	AMN082	Agonist	99.73%	Unkown
HY-10159S	Nilotinib-d6		99.95%	Unkown
HY-10159C	Nilotinib hydrochloride dihydrate		99.89%	Unkown
HY-RS00068	ABCD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-103565A	AMN082 free base	Agonist	98.37%	Unkown
HY-10159S1	Nilotinib-13C,d3		/	Unkown
HY-RS00661	AMN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00662	AMN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-134360A	ATP-1-Aminonaphthalene-5-sulfonate sodium		/	Unkown
HY-137604A	(γ-AmNS)UTP trisodium		/	Unkown
HY-137678A	GTP-γ-AmNS trisodium		/	Unkown
HY-168917	9-Aminominocycline	Inhibitor	/	Unkown
HY-RS17996	Traf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18731	Amn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25218	Amn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AMN	MGD	MGI:1934943
Bos taurus	AMN	VGNC	VGNC:25869
Rattus norvegicus	AMN	RGD	RGD:1308634
Macaca mulatta	AMN	VGNC	VGNC:107993
Others	AMN	NCBI