2. Protein Tyrosine Kinase/RTK Autophagy
  3. Bcr-Abl Autophagy
  4. Nilotinib-d6

Nilotinib-d6  (Synonyms: AMN107-d6)

Cat. No.: HY-10159S Purity: 99.95%
COA Handling Instructions

Nilotinib-d6 is a deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity[1].

For research use only. We do not sell to patients.

Nilotinib-d<sub>6</sub> Chemical Structure

Nilotinib-d6 Chemical Structure

CAS No. : 1268356-17-7

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5 mg USD 1000 In-stock
10 mg USD 1600 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Nilotinib-d6:

Nilotinib-d6 Related Antibodies

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Description

Nilotinib-d6 is a deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity[1].

Molecular Weight

535.55

Appearance

Solid

Formula

C28H16D6F3N7O
CAS No.
SMILES

O=C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)C3=C([2H])C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C(C([2H])([2H])[2H])C([2H])=C3[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (233.40 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8672 mL 9.3362 mL 18.6724 mL
5 mM 0.3734 mL 1.8672 mL 3.7345 mL
10 mM 0.1867 mL 0.9336 mL 1.8672 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.88 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.95%

COA (251 KB) HNMR (217 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References
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Nilotinib-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Nilotinib-d61268356-17-7AMN107-d6Bcr-AblAutophagyNilotinibInhibitorinhibitorinhibit

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