Pde1c - phosphodiesterase 1C Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81742

Summary

Enables cAMP binding activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of Insulin secretion involved in cellular response to glucose stimulus and sensory perception of smell. Acts upstream of or within response to calcium ion. Located in neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to human PDE1C (phosphodiesterase 1C). [provided by Alliance of Genome Resources, Apr 2022]

Pde1c Products (1)

mRNA Protein Name
NM_031078.2 NP_112340.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cAMP binding IDA
IDA: Inferred from direct assay
7568196 RGD
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
7568196 RGD
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
7568196 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
18706893 RGD
acts upstream of or within response to calcium ion IDA
IDA: Inferred from direct assay
7568196 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
16881052 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

  • 3',5'-cyclic-AMP phosphodiesterase

  • 3',5'-cyclic-GMP phosphodiesterase

  • cam-PDE 1C

  • cyclic nucleotide phosphodiesterase 1 C

  • dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

  • phosphodiesterase 1C calmodulin-depend

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12501A ITI-214 Inhibitor 99.56% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-12501 ITI-214 free base Inhibitor 98.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101490 PDE1-IN-2 Inhibitor 98.0% Unkown
HY-169402 PDE1-IN-9 Inhibitor / Unkown
HY-169402A PDE1-IN-9 hydrochloride Inhibitor / Unkown
HY-120741 PF-04822163 Inhibitor / Unkown
HY-120195 PF-04677490 Inhibitor / Unkown
HY-120195A PF-04827736 Inhibitor / Unkown
HY-147946 PDE1-IN-4 Inhibitor / Unkown
HY-155199 PDE1-IN-5 Inhibitor / Unkown
HY-RS10212 PDE1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N11262 Sudachitin / Unkown
HY-RS19228 Pde1c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25717 Pde1c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00374 Sch59498 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde1c NCBI NCBI:5137