H3C6 - H3 clustered histone 6 Gene

Also Known as H3.1; H3/d; H3C1; H3C2; H3C3; H3C4; H3C7; H3C8; H3FD; H3C10; H3C11; H3C12; HIST1H3E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8353

About H3C6

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,224,178-26,227,473 (from NCBI)

This gene has 2 transcripts (splice variants), 72 orthologues and 20 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H3C6 Products (2)

mRNA Protein Name
NM_001381999.1 NP_001368928.1 histone H3.1
NM_003532.3 NP_003523.1 histone H3.1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IDA
IDA: Inferred from direct assay
30867594 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10949293 GOA
Biological Process GO Annotation Evidence References Source
involved in epigenetic regulation of gene expression IDA
IDA: Inferred from direct assay
16267050 GOA
acts upstream of positive effect gene expression IDA
IDA: Inferred from direct assay
30867594 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
14718166 GOA
involved in nucleosome assembly IMP
IMP: Inferred from mutant phenotype
25615412 GOA
Cellular Component GO Annotation Evidence References Source
part of nucleosome IDA
IDA: Inferred from direct assay
14718166 GOA
part of nucleosome IPI
IPI: Inferred from physical interaction
21812398 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21636898 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
14718166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H3C6 Protein Structure

Histone

Histone: Core histone H2A/H2B/H3/H4 (58 - 132)

  • 0
  • 100
  • 136 a.a.
Protein Preferred Names Protein Names

histone H3.1

  • H3 histone family, member D

Recombinant H3C6 Proteins

Cat. No. Product Name Accession Purity
HY-P72332 Histone H3 Protein, Human P68431 (A2-A136) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72335 Histone H3 Protein, Human (98a.a, His) P68431 (P39-A136) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72798 Histone H3 Protein, Human (His) P68431 (A2-A136) ≥ 90%, as determined by reducing SDS-PAGE.

H3C6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80166 Histone H3 Antibody (YA368) WB, ICC/IF, IHC-P, IP, ChIP Human, Mouse, Rat
HY-P85644 Histone H3 Antibody(HRP) (YA5336) WB Zebrafish
HY-P85652 Histone H3 Antibody (YA5344) WB, ICC/IF, ELISA Human, Mouse, Rat
HY-P85670 Histone H3 (Di Methyl Lys79) Antibody (YA5362) WB Human, Mouse, Rat
HY-P85671 Histone H3 (Tri Methyl Lys36) Antibody (YA5363) WB, IP Human, Mouse, Rat
HY-P86071 Histone H3 (Tri Methyl Lys36) Antibody (YA5763) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat
HY-P86113 Histone H3 (Di Methyl Lys4) Antibody (YA5805) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat
HY-P86144 Histone H3 (Acetyl Lys36) Antibody (YA5836) WB, IHC-P, ICC/IF, IP, ChIP, ELISA Human, Mouse, Rat
HY-P86148 Histone H3 (Di Methyl Lys9) Antibody (YA5840) WB, IHC-P, ICC/IF, IP, ChIP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Histone Mutated Tumor

  • Histone Mutated Tumour
Brain Stem Cancer

  • Brain Stem Neoplasms

  • Malignant Neoplasm Of Brain Stem

  • Malignant Neoplasm Of Brainstem

  • Neoplasm Of Adult Brain Stem

  • Neoplasm Of Brain Stem

  • Primary Brain Stem Neoplasm

  • Primary Brain Stem Tumor

  • Brain Stem Neoplasm

  • Brain Stem--Cancer

  • Brain Stem Neoplasms, Primary
Diffuse Midline Glioma, H3 K27m-Mutant

  • Diffuse Intrinsic Pontine Glioma

  • Dipg

  • Infiltrative Brainstem Glioma
Childhood Brain Stem Glioma

  • Pediatric Glioma Of The Brainstem
Adult Brainstem Astrocytoma

  • Adult Brain Stem Astrocytoma
Hutchinson-Gilford Progeria Syndrome

  • Progeria

  • HGPS

  • Hutchinson-Gilford Syndrome

  • Hutchinson-Gilford Progeria

  • Hutchinson Gilford Syndrome

  • Hutchinson Gilford Progeria Syndrome

  • Hutchinson-Gilford Disease

  • Progeria Of Childhood

  • Hutchinson-Gilford-Progeria Syndrome
Posterior Fossa Ependymoma
Clear Cell Chondrosarcoma

  • Chondrosarcoma, Clear Cell
Brain Stem Glioma

  • Brainstem Glioma

  • Brainstem Neuroglial Tumor

  • Glioma Of Brainstem
Spinal Cord Astrocytoma

  • Astrocytoma Of Spinal Cord

  • Spinal Astrocytoma
Diffuse Large B-Cell Lymphoma

  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma
Spinal Cord Glioma

  • Glial Tumor Of Spinal Cord

  • Glial Neoplasm Spinal Cord

  • Glioma Of Spinal Cord
Anaplastic Pleomorphic Xanthoastrocytoma
Charcot-Marie-Tooth Disease, X-Linked Recessive, 3

  • CMTX3

  • Charcot-Marie-Tooth Disease X-Linked Recessive 3

  • Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 3

  • Cmt3x

  • X-Linked Charcot-Marie-Tooth Disease Type 3

  • Charcot-Marie-Tooth Neuropathy X-Linked Recessive 3

  • Charcot-Marie-Tooth Disease, X-Linked Type 3, Recessive
Hyperinsulinemic Hypoglycemia, Familial, 3

  • HHF3

  • Hyperinsulinism Due To Glucokinase Deficiency

  • Familial Hyperinsulinemic Hypoglycemia 3

  • Hyperinsulinemic Hypoglycemia Due To Glucokinase Deficiency

  • Hyperinsulinemic Hypoglycemia Familial 3

  • Congenital Hyperinsulinism

  • Persistent Hyperinsulinemic Hypoglycemia Of Infancy

  • Phhi

  • Hypoglycemia, Hyperinsulinemic, Familial, Type 3
High Grade Ependymoma

  • Ependymal Neoplasm

  • Ependymal Tumors

  • Malignant Ependymoma

  • Ependymal Tumor

  • Anaplastic Ependymoma

  • Experimental Organism Malignant Ependymoma

  • Ependymoma Of Brain
Astrocytoma, Idh-Mutant, Grade 4

  • Idh-Mutant Glioblastoma
Pleomorphic Xanthoastrocytoma

  • Pxa

  • Pleomorphic Xantho-Astrocytoma
Idh-Wildtype Glioblastoma
Juvenile Pilocytic Astrocytoma
Diffuse Astrocytoma

  • Diffuse Astrocytoma, Low Grade

  • Who Grade Ii Astrocytoma

  • Fibrillary Astrocytoma

  • Gemistocytic Astrocytoma

  • Low-Grade Diffuse Astrocytoma

  • Protoplasmic Astrocytoma
Spinal Cancer

  • Spinal Cord Neoplasm

  • Spinal Cord Neoplasms

  • Spinal Neoplasms

  • Intraspinal Tumor

  • Malignant Tumor Of The Spinal Cord

  • Spinal Cord Cancer

  • Spinal Neoplasm

  • Tumor Of The Spinal Cord

  • Tumors Spinal Cord

  • Intraspinal Neoplasm

  • Spinal Cord--Cancer
Pilomyxoid Astrocytoma
Cerebral Ventricle Cancer

  • Cerebral Ventricle Neoplasms

  • Cerebral Ventricle Neoplasm

  • Intraventricular Tumor Of Brain
Supratentorial Ependymoma
Intracranial Cavernous Angioma

  • Intracranial Cavernoma

  • Intracranial Cavernous Hemangioma
Intracranial Structure Hemangioma

  • Angioma Of Intracranial Structure

  • Hemangioma Of Intracranial Structure

  • Hemangioma Of Intracranial Structures
Low Grade Glioma

  • Benign Glioma
Central Nervous System Benign Neoplasm

  • Benign Neoplasm Of The Central Nervous System
Supratentorial Cancer

  • Supratentorial Neoplasms

  • Brain Neoplasm, Supratentorial

  • Malignant Supratentorial Tumor

  • Cancer, Supratentorial
Cerebrum Cancer

  • Cerebral Cancer

  • Neoplasm Of Cerebrum

  • Tumor Of Cerebrum

  • Malignant Neoplasm Of Cerebrum
Pilocytic Astrocytoma

  • Juvenile Pilocytic Astrocytoma

  • Grade I Astrocytic Tumor

  • Piloid Astrocytoma
Atypical Teratoid Rhabdoid Tumor

  • Rhabdoid Tumor Predisposition Syndrome

  • Rtps

  • Atypical Teratoid/Rhabdoid Tumor

  • Rhabdoid Predisposition Syndrome

  • Familial Posterior Fossa Brain Tumor Of Infancy

  • Familial Rhabdoid Tumor

  • At/Rt

  • Atypical Teratoid Rhabdoid Tumour

  • Atypical Teratoid/Rhabdoid Tumour

  • Rhabdoid Tumor Of The Cns

  • Rhabdoid Tumour Of The Cns

  • Familial Posterior Fossa Brain Tumor Syndrome

  • Hereditary Swi/Snf Deficiency Syndrome

  • Atrt
Infratentorial Cancer

  • Infratentorial Neoplasms

  • Brain Neoplasm, Infratentorial

  • Malignant Infratentorial Tumors
Spinal Cord Disease

  • Spinal Cord Diseases

  • Myelopathy

  • Bone Marrow Diseases
Anaplastic Oligodendroglioma
Anaplastic Astrocytoma

  • Grade Iii Astrocytoma

  • Astrocytoma, Anaplastic

  • Grade Iii Astrocytic Tumor
Alpha-Thalassemia

  • Alpha Thalassemia

  • Alpha Thalassaemia

  • Alpha Plus Thalassemia

  • Thalassemia, Alpha-

  • Thalassemias, Alpha-

  • A-Thalassemia

  • Α-Thalassemia

  • A-THAL

  • Thalassemia

  • Alpha Thalassaemia Syndrome
Giant Cell Glioblastoma

  • Monstrocellular Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05966 H3C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05968 H3C2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05969 H3C3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05970 H3C6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05971 H3C7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05972 H3C8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus H3C6 MGD MGI:2448349
Rattus norvegicus H3C6 RGD RGD:1311554