TSSK6 - testis specific serine kinase 6 Gene

Also Known as CT72; SSTK; TSSK4; FKSG82

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83983

About TSSK6

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,514,219-19,515,548 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and 17 paralogues.

Summary

This intronless gene encodes a member of the CaMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]

TSSK6 Products (1)

mRNA Protein Name
NM_032037.4 NP_114426.1 testis-specific serine/threonine-protein kinase 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables ATP binding IDA
IDA: Inferred from direct assay
15870294 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
15870294 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15870294 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15870294 GOA
Biological Process GO Annotation Evidence Références Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15870294 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSSK6 Protein Structure

Pkinase

Pkinase: Protein kinase domain (12 - 266)

  • 0
  • 100
  • 200
  • 273 a.a.
Protein Preferred Names Protein Names

testis-specific serine/threonine-protein kinase 6

  • TSK-6

TSSK6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TSSK6 Q9BXA6 CDC37 Homo sapiens Q16543
Pull Down
32707033
Intra
TSSK6 Q9BXA6 CDC37 Homo sapiens Q16543
Anti Tag CoIP
33961781
Intra
TSSK6 Q9BXA6 HSP90AA1 Homo sapiens P07900
Lumier
25036637
Intra
TSSK6 Q9BXA6 HSP90AA1 Homo sapiens P07900
Anti Tag CoIP
33961781
Intra
TSSK6 Q9BXA6 HSP90AA1 Homo sapiens P07900
Pull Down
32707033
Intra
TSSK6 Q9BXA6 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
15870294
Intra
TSSK6 Q9BXA6 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra
TSSK6 Q9BXA6 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
33961781
Intra
TSSK6 Q9BXA6 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Oligospermia
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS15189 TSSK6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22886 Tssk6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29400 Tssk6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TSSK6 MGD MGI:2148775
Rattus norvegicus TSSK6 RGD RGD:1559764
Canis familiaris TSSK6 VGNC VGNC:55009
Bos taurus TSSK6 VGNC VGNC:50152
Felis catus TSSK6 VGNC VGNC:66646
Others TSSK6 NCBI