Usp8 - ubiquitin specific peptidase 8 Gene

Also Known as Ubpy; mKIAA0055

Species: Mus musculus

Gene Type: protein coding
Gene ID: 84092

Summary

Enables thiol-dependent Deubiquitinase. Involved in endosome organization and protein deubiquitination. Acts upstream of or within Ras protein signal transduction. Located in acrosomal membrane; cytosol; and midbody. Is extrinsic component of endosome membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Apr 2022]

Usp8 Products (2)

mRNA Protein Name
NM_001252580.1 NP_001239509.1 ubiquitin carboxyl-terminal hydrolase 8 isoform 1
NM_019729.3 NP_062703.2 ubiquitin carboxyl-terminal hydrolase 8 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
11500497 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10982817 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Ras protein signal transduction IPI
IPI: Inferred from physical interaction
11500497 MGI
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
16771824 MGI
acts upstream of or within protein deubiquitination IDA
IDA: Inferred from direct assay
15342353 MGI
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
16120644 MGI
involved in protein deubiquitination IMP
IMP: Inferred from mutant phenotype
15314180 MGI
Cellular Component GO Annotation Evidence References Source
located in acrosomal membrane IDA
IDA: Inferred from direct assay
15342353 MGI
located in cytosol IDA
IDA: Inferred from direct assay
16120644 MGI
located in endosome membrane IDA
IDA: Inferred from direct assay
16120644 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
11500497 MGI
located in midbody IDA
IDA: Inferred from direct assay
18388320 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 8

  • deubiquitinating enzyme 8

  • putative deubiquitinating enzyme

  • ubiquitin isopeptidase Y

  • ubiquitin thioesterase 8

  • ubiquitin thiolesterase 8

  • ubiquitin-specific-processing protease 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162312 LLK203 Inhibitor 98.58% Unkown
HY-151563A OTUB1/USP8-IN-1 TFA Inhibitor 99.56% Unkown
HY-149902 USP8-IN-3 Inhibitor 98.37% Unkown
HY-149901 USP8-IN-2 Inhibitor 99.91% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Usp8 NCBI NCBI:9101