Tcf4 - transcription factor 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84382

Summary

Enables bHLH transcription factor binding activity and double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and nucleus. Predicted to be part of beta-catenin-TCF7L2 complex. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Tcf4 Products (1)

mRNA Protein Name
NM_053369.2 NP_445821.2 transcription factor 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
15831523 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
7913462 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7913462 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor 4

  • ITF-2

  • R8f DNA-binding protein

  • RITF-2

  • SEF-2

  • SL3-3 enhancer factor 2

  • TCF-4

  • immunoglobulin transcription factor 2

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1360 Chlorquinaldol 98.69% Unkown

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101486 LF3 Antagonist 99.55% Unkown
HY-100760 Toxoflavin Inhibitor 99.88% Unkown
HY-P10392B aStAx-35R TFA 99.07% Unkown
HY-119966 CCT036477 Inhibitor 99.42% Unkown
HY-122649 UU-T01 Inhibitor 99.88% Unkown
HY-100760S Toxoflavin-13C4 Inhibitor / Unkown
HY-124826 BC21 Inhibitor / Unkown
HY-149858 β-catenin-IN-7 Inhibitor / Unkown
HY-157126 Pterostilbene-isothiocyanate Inhibitor / Unkown
HY-172393 TCF4/β-catenin-IN-1 / Unkown
HY-181560 SLD1121 Agonist / Unkown
HY-N3393 Lethedioside A Inhibitor / Unkown
HY-P10392 aStAx-35R / Unkown
HY-P11660 β-catenin-IN-10 Inhibitor / Unkown
HY-RS14307 TCF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14310 TCF7L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-133093 Murayaquinone Inhibitor / Unkown
HY-RS17416 Tcf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17858 Tcf7l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23870 Tcf4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tcf4 NCBI NCBI:6925