Cxcr3 - C-X-C motif chemokine receptor 3 Gene

Also Known as Gpr9

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84475

About Cxcr3

Primary_assembly X: 66,844,318-66,846,969 reverse strand.mRatBN7.2:CM026994.1

This gene has 2 transcripts (splice variants), 289 orthologues, 24 paralogues and is associated with 47 phenotypes. Biased expression in Spleen (RPKM 53.), Thymus (RPKM 34.7) and 7 other tissues.

Summary

Enables C-X-C Chemokine Receptor activity. Involved in T cell chemotaxis; calcium-mediated signaling; and positive regulation of cytosolic calcium ion concentration. Located in external side of plasma membrane. Used to study dilated cardiomyopathy; high grade glioma; myocarditis; and renovascular hypertension. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CXCR3 (C-X-C motif Chemokine Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr3 Products (1)

mRNA Protein Name
NM_053415.1 NP_445867.1 C-X-C chemokine receptor type 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables C-X-C chemokine receptor activity IPI
IPI: Inferred from physical interaction
10825390 RGD
Biological Process GO Annotation Evidence References Source
involved in T cell chemotaxis IMP
IMP: Inferred from mutant phenotype
21038468 RGD
involved in calcium-mediated signaling IDA
IDA: Inferred from direct assay
10825390 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
10825390 RGD
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
16434036 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cxcr3 Protein Structure

7tmA_CXCR3

7tmA_CXCR3: cd15180 (52 - 327)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (52 - 79)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (86 - 111)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (122 - 152)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (164 - 186)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (210 - 239)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (246 - 276)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (295 - 320)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
Protein Preferred Names Protein Names

C-X-C chemokine receptor type 3

  • CXC-R3

  • CXCR-3

  • G protein-coupled receptor 9

  • IP-10 receptor

  • chemokine (C-X-C motif) receptor 3

  • interferon-inducible protein 10 receptor

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0426A Olopatadine hydrochloride Inhibitor 99.83% Unkown

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15319 AMG 487 Inhibitor 99.89% Unkown
HY-13406 TAK-779 Antagonist 99.89% Unkown
HY-10017 SCH 546738 Antagonist 98.71% Unkown
HY-149055 ACT-777991 Antagonist 99.86% Unkown
HY-15320 NBI-74330 Antagonist 99.76% Unkown
HY-111149A PS372424 hydrochloride Agonist ≥98.0% Unkown
HY-15319B AMG 487 (S-enantiomer) Antagonist 99.94% Unkown
HY-128063 CXCR3 antagonist 1 Antagonist 98.6% Unkown
HY-165428 SCH-900875 Inhibitor 98.16% Unkown
HY-151096 ACT-660602 Antagonist 99.02% Unkown
HY-111149 PS372424 Agonist / Unkown
HY-N16578 Hypoglaucin A Antagonist / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990254 Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) Inhibitor 99% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcr3 NCBI NCBI:2833