Foxo1 - forkhead box O1 Gene

Also Known as Fkhr; Foxo1a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84482

Summary

Enables DNA-binding transcription factor activity; sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; enamel mineralization; and regulation of transcription, DNA-templated. Located in cytosol and nucleus. Used to study non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1). [provided by Alliance of Genome Resources, Apr 2022]

Foxo1 Products (1)

mRNA Protein Name
NM_001191846.3 NP_001178775.1 forkhead box protein O1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10960473 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17916612 RGD
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
19273580 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
19443572 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
22417654 RGD
involved in enamel mineralization IEP
IEP: Inferred from expression pattern
25183529 RGD
involved in negative regulation of cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
26436652 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17916612 RGD
involved in positive regulation of smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19483080 RGD
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10960473 RGD
involved in regulation of transcription initiation by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19483080 RGD
involved in response to fluoride IEP
IEP: Inferred from expression pattern
25183529 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
20501667 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19483080 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein O1

  • Forkhead box protein O1A

  • Forkhead in rhabdomyosarcoma

  • forkhead box O1A (rhabdomyosarcoma)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13024 Rebastinib Inhibitor 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2440 Gypenoside A Activator 99.79% Unkown
HY-137038 N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride Inhibitor / Unkown
HY-13024A Rebastinib tosylate Inhibitor / Unkown
HY-184415 Syk/HDAC6-IN-1 Inhibitor / Unkown
HY-179498 ROCK2-IN-13 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxo1 NCBI NCBI:2308