PLA2G12B - phospholipase A2 group XIIB Gene

Homo sapiens

Also known as GXIIB; FKSG71; PLA2G13; GXIIIsPLA2; sPLA2-GXIIB

Gene ID: 84647 | Gene type: protein coding

About PLA2G12B

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,934,762-72,954,806 (from NCBI)

This gene has 1 transcript (splice variant), 271 orthologues and 1 paralogue. Biased expression in liver (RPKM 15.3), small intestine (RPKM 14.6) and 5 other tissues.

Summary

The protein encoded by this gene belongs to the Phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

PLA2G12B Products(3)

mRNA	Protein	Name
NM_001318124.2	NP_001305053.1	group XIIB secretory phospholipase A2-like protein isoform b precursor
NM_001318125.2	NP_001305054.1	group XIIB secretory phospholipase A2-like protein isoform c
NM_032562.5	NP_115951.2	group XIIB secretory phospholipase A2-like protein isoform a precursor

PLA2G12B Protein Structure

PLA2G12

0
100
195 a.a.

Protein Preferred Names

Protein Names

group XIIB secretory phospholipase A2-like protein

group XIII secreted phospholipase A2

Related Diseases

Diseases

Alias

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Spastic Paraplegia 39, Autosomal Recessive

SPG39	Ntemnd
Hereditary Spastic Paraplegia 39	Nte-Related Motor Neuron Disorder
Autosomal Recessive Spastic Paraplegia Type 39	Spastic Paraplegia Due To Neuropathy Target Esterase Mutation
Spastic Paraplegia Due To Nte Mutation	Spastic Paraplegia 39
Autosomal Recessive Spastic Paraplegia 39	Nte Related Motor Neuron Disorder
Paraplegia, Spastic, Type 39

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10618	PLA2G12B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLA2G12B	RGD	RGD:1588484
Bos taurus	PLA2G12B	VGNC	VGNC:32955
Macaca mulatta	PLA2G12B	VGNC	VGNC:76059
Mus musculus	PLA2G12B	MGD	MGI:1917086
Canis familiaris	PLA2G12B	VGNC	VGNC:44620
Others	PLA2G12B	NCBI

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