CAMK1 - calcium/calmodulin dependent protein kinase I Gene

Also Known as CAMKI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8536

About CAMK1

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,757,347-9,769,947 (from NCBI)

This gene has 6 transcripts (splice variants), 270 orthologues and 22 paralogues. Broad expression in adrenal (RPKM 42.3), fat (RPKM 25.3) and 22 other tissues.

Summary

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/Calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]

CAMK1 Products (1)

mRNA Protein Name
NM_003656.5 NP_003647.1 calcium/calmodulin-dependent protein kinase type 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17442826 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
23867755 GOA
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
23867755 GOA
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
18184567 GOA
involved in positive regulation of muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
11081517 GOA
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
17442826 GOA
involved in positive regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
23867755 GOA
involved in positive regulation of protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
17442826 GOA
involved in positive regulation of synapse structural plasticity IMP
IMP: Inferred from mutant phenotype
18184567 GOA
involved in positive regulation of syncytium formation by plasma membrane fusion IMP
IMP: Inferred from mutant phenotype
23867755 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23867755 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11114197 GOA
involved in regulation of muscle cell differentiation IDA
IDA: Inferred from direct assay
11114197 GOA
involved in regulation of protein binding IDA
IDA: Inferred from direct assay
11114197 GOA
involved in regulation of protein localization IDA
IDA: Inferred from direct assay
11114197 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (22 - 276)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase type 1

  • caM kinase I alpha

CAMK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAMK1 Q14012 CAMK1D Homo sapiens Q8IU85
Pull Down
32707033
Intra
CAMK1 Q14012 ATXN1 Homo sapiens P54253
Y2H Prey Pooling
32296183
Intra
CAMK1 Q14012 ATXN1 Homo sapiens P54253
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAMK1 Proteins

Cat. No. Product Name Accession Purity
HY-P7714 CAMKI alpha/CAMK1 Protein, Human (Active, HEK293, His) Q14012 (M1-L370) ≥ 90%, as determined by reducing SDS-PAGE.

CAMK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80580 CaMK1 Antibody (YA570) WB Mouse, Rat
HY-P80580A CaMK1 Antibody (YA570)(PBS only) WB Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148907 CS640 Inhibitor 99.48% Unkown
HY-148913 CS587 Inhibitor 98.18% Unkown
HY-156871 CAMK1D-IN-1 Inhibitor 99.06% Unkown
HY-RS01852 CAMK1D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-143898 PIM1-IN-4 Inhibitor / Unkown
HY-E70810 CaMK1β Recombinant Human Active Protein Kinase / Unkown
HY-P10282 Synapsin I-(3-13) / Unkown
HY-RS01851 CAMK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01853 CAMK1G Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17384 Camk1d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18167 Camk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20530 Camk1g Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23839 Camk1d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24641 Camk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27039 Camk1g Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CAMK1 VGNC VGNC:60328
Rattus norvegicus CAMK1 RGD RGD:629473
Mus musculus CAMK1 MGD MGI:1098535
Bos taurus CAMK1 VGNC VGNC:26719
Macaca mulatta CAMK1 VGNC VGNC:70522
Canis familiaris CAMK1 VGNC VGNC:38677
Others CAMK1 NCBI