TRIM5 - tripartite motif containing 5 Gene

Also Known as RNF88; TRIM5alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 85363

About TRIM5

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:5,588,635-5,685,074 (from NCBI)

This gene has 14 transcripts (splice variants), 173 orthologues and 80 paralogues. Ubiquitous expression in urinary bladder (RPKM 5.4), endometrium (RPKM 5.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

TRIM5 Products (8)

mRNA	Protein	Name
NM_001410958.1	NP_001397887.1	tripartite motif-containing protein 5 isoform 4
NM_033034.3	NP_149023.2	tripartite motif-containing protein 5 isoform alpha
NM_033092.4	NP_149083.2	tripartite motif-containing protein 5 isoform gamma
NM_033093.4	NP_149084.2	tripartite motif-containing protein 5 isoform delta
NM_001410958.1	NP_001397887.1	tripartite motif-containing protein 5 isoform 4
NM_033034.3	NP_149023.2	tripartite motif-containing protein 5 isoform alpha
NM_033092.4	NP_149083.2	tripartite motif-containing protein 5 isoform gamma
NM_033093.4	NP_149084.2	tripartite motif-containing protein 5 isoform delta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17156811	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	21512573	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12878161	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11331580	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25127057	GOA
enables protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	25127057	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	21512573	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	21512573	GOA
involved in autophagy	IDA IDA: Inferred from direct assay	25127057	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	21512573	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	21512573	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21512573	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	21512573	GOA
involved in regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21512573	GOA
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	25127057	GOA
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	18248090	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	12878161	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11331580	GOA
colocalizes with omegasome	IDA IDA: Inferred from direct assay	25127057	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM5 Protein Structure

zf-C3HC4_4

zf-B_box

SPRY

0
100
200
300
400
493 a.a.

Protein Preferred Names	Protein Names
tripartite motif-containing protein 5	RING-type E3 ubiquitin transferase TRIM5

TRIM5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM5	Q9C035	SNAI1	Homo sapiens	O95863	Anti Tag CoIP	25203322
Intra	TRIM5	Q9C035	TRIM32	Homo sapiens	Q13049	Y2H Array	22493164
Intra	TRIM5	Q9C035	TRIM32	Homo sapiens	Q13049	Anti Tag CoIP	22493164
Intra	TRIM5	Q9C035	UBE2N	Homo sapiens	P61088	Y2H Array	19549727
Intra	TRIM5	Q9C035	TRIM5	Homo sapiens	Q9C035	Anti Tag CoIP	22493164
Intra	TRIM5	Q9C035	TRIM5	Homo sapiens	Q9C035	Y2H	22829933
Intra	TRIM5	Q9C035	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	TRIM5	Q9C035	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	19549727
Intra	TRIM5	Q9C035	TRIM34	Homo sapiens	Q9BYJ4	Y2H Array	22493164
Intra	TRIM5	Q9C035	MNAT1	Homo sapiens	P51948	Y2H Array	22493164
Intra	TRIM5	Q9C035	TRIM5	Homo sapiens	Q9C035	Y2H Array	22493164

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TRIM5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71385	TRIM5 Protein, Human (His)	Q9C035-1 (M1-Q248)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71637	TRIM5 Protein, Human (His, B2M)	Q9C035-1 (M1-S493)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P71385A	TRIM5 Protein, Human (N-His)	Q9C035-1 (M1-Q248)	≥ 95%, as determined by reducing SDS-PAGE.

TRIM5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84781	Trim5a Antibody (YA4478)	WB, IHC-P, ELISA	Human
HY-P84781A	Trim5a Antibody (YA4478)(PBS only)	WB, IHC-P, ELISA	Human
HY-P85395	Trim5a Antibody (YA5087)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Rubella	German Measles Three Day Measles Rubella Nos
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Mulibrey Nanism	MUL Muscle-Liver-Brain-Eye Nanism Pericardial Constriction And Growth Failure Perheentupa Syndrome Mulibrey Growth Disorder Mulibrey Nanism Syndrome Pericardial Constriction With Growth Failure Nanism Mulibrey
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15053	TRIM5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18412	Trim5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24893	Trim5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIM5	RGD	RGD:1304579
Mus musculus	TRIM5	MGD	MGI:3646853
Macaca mulatta	TRIM5	VGNC	VGNC:106441
Others	TRIM5	NCBI