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GALR2 - galanin receptor 2 Gene

Also Known as GAL2-R; GALNR2; GALR-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8811

About GALR2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,071,962-76,077,537 (from NCBI)

This gene has 1 transcript (splice variant), 177 orthologues and 23 paralogues. Low expression observed in reference dataset.

Summary

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of Galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the Galanin peptide. The primary signaling mechanism for GALR2 is through the Phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]

GALR2 Products (1)

mRNA	Protein	Name
NM_003857.4	NP_003848.1	galanin receptor type 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables galanin receptor activity	IDA IDA: Inferred from direct assay	9832121	GOA
enables peptide hormone binding	IDA IDA: Inferred from direct assay	24517231	GOA
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	9832121	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23597562	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in galanin-activated signaling pathway	IDA IDA: Inferred from direct assay	9832121	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9832121	GOA
involved in positive regulation of large conductance calcium-activated potassium channel activity	IMP IMP: Inferred from mutant phenotype	24602615	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24517231	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cilium	IDA IDA: Inferred from direct assay	28154160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALR2 Protein Structure

7tm_1

0
100
200
300
387 a.a.

Protein Preferred Names	Protein Names
galanin receptor type 2

GALR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GALR2	O43603	P22466-PRO_0000010449	Homo sapiens	P22466-PRO_0000010449	SPA	23597562

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Arboleda-Tham Syndrome	Kat6a Syndrome Autosomal Dominant Intellectual Disability-Craniofacial Anomalies-Cardiac Defects Syndrome ARTHS Mrd32 Mental Retardation, Autosomal Dominant 32, Formerly Mrd32, Formerly Autosomal Dominant Mental Retardation 32 Autosomal Dominant Non-Syndromic Intellectual Disability 32 Arboleda-Tham
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1127	Galanin (1-30), human	Agonist	99.91%	Unkown
HY-P1130	M871	Antagonist	99.98%	Unkown
HY-123671	CYM2503	Modulator	96.01%	Unkown
HY-RS05265	GALR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P1129	AR-M1896	Agonist	/	Unkown
HY-P5064	Galanin-Like Peptide (porcine)	Agonist	/	Unkown
HY-P5894	human GALP (3-32)	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GALR2	VGNC	VGNC:29240
Rattus norvegicus	GALR2	RGD	RGD:2657
Mus musculus	GALR2	MGD	MGI:1337018
Canis familiaris	GALR2	VGNC	VGNC:41101
Macaca mulatta	GALR2	VGNC	VGNC:104602
Others	GALR2	NCBI