2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. CYM2503

CYM2503 is a putative GalR2-positive allosteric modulator. CYM2503 increases the latency to first electrographic seizure and decreases the total time in seizure. CYM2503 also attenuates electroshock-induced seizures in mice. Galanin receptors type 1 (GalR1) and/or type 2 (GalR2) represent unique pharmacological targets for the research of seizures and epilepsy.

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CYM2503 Chemical Structure

CYM2503 Chemical Structure

CAS No. : 1308833-36-4

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10 mg USD 240 In-stock
25 mg USD 480 In-stock
50 mg USD 768 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

CYM2503 is a putative GalR2-positive allosteric modulator. CYM2503 increases the latency to first electrographic seizure and decreases the total time in seizure. CYM2503 also attenuates electroshock-induced seizures in mice. Galanin receptors type 1 (GalR1) and/or type 2 (GalR2) represent unique pharmacological targets for the research of seizures and epilepsy[1].

Molecular Weight

777.95

Formula

C45H55N5O7
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C1=CC=C(C=C1N2)NC([C@H](CCCCNC(OC(C)(C)C)=O)NC([C@H](CC3CCCCC3)NC(OCC4C5=CC=CC=C5C6=CC=CC=C64)=O)=O)=O)=CC2=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (128.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2854 mL 6.4271 mL 12.8543 mL
5 mM 0.2571 mL 1.2854 mL 2.5709 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 96.01%

COA (252 KB) HNMR (312 KB) LCMS (90 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2854 mL 6.4271 mL 12.8543 mL 32.1357 mL
5 mM 0.2571 mL 1.2854 mL 2.5709 mL 6.4271 mL
10 mM 0.1285 mL 0.6427 mL 1.2854 mL 3.2136 mL
15 mM 0.0857 mL 0.4285 mL 0.8570 mL 2.1424 mL
20 mM 0.0643 mL 0.3214 mL 0.6427 mL 1.6068 mL
25 mM 0.0514 mL 0.2571 mL 0.5142 mL 1.2854 mL
30 mM 0.0428 mL 0.2142 mL 0.4285 mL 1.0712 mL
40 mM 0.0321 mL 0.1607 mL 0.3214 mL 0.8034 mL
50 mM 0.0257 mL 0.1285 mL 0.2571 mL 0.6427 mL
60 mM 0.0214 mL 0.1071 mL 0.2142 mL 0.5356 mL
80 mM 0.0161 mL 0.0803 mL 0.1607 mL 0.4017 mL
100 mM 0.0129 mL 0.0643 mL 0.1285 mL 0.3214 mL
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CYM2503 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYM25031308833-36-4CYM 2503CYM-2503Neuropeptide Y ReceptorNPY receptorGalR2electrographic seizureseizureepilepsyInhibitorinhibitorinhibit

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