CES2 - carboxylesterase 2 Gene

Homo sapiens

Also known as iCE; CE-2; PCE-2; CES2A1

Gene ID: 8824 | Gene type: protein coding

About CES2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:66,934,471-66,945,096 (from NCBI)

This gene has 12 transcripts (splice variants), 721 orthologues and 13 paralogues. Biased expression in duodenum (RPKM 209.7), small intestine (RPKM 176.0) and 8 other tissues.

Summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and Cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal Enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

CES2 Products(6)

mRNA	Protein	Name
NM_001365405.1	NP_001352334.1	cocaine esterase isoform 1 precursor
NM_001365406.1	NP_001352335.1	cocaine esterase isoform 3
NM_001365407.1	NP_001352336.1	cocaine esterase isoform 3
NM_001365408.1	NP_001352337.1	cocaine esterase isoform 4
NM_003869.6	NP_003860.3	cocaine esterase isoform 1 precursor
NM_198061.3	NP_932327.2	cocaine esterase isoform 2 precursor

CES2 Protein Structure

COesterase

0
100
200
300
400
500
623 a.a.

Protein Preferred Names

Protein Names

cocaine esterase

carboxylesterase 2 (intestine, liver)

Recombinant CES2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76192	CES2/carboxylesterase 2 Protein, Human (HEK293,C-His)	O00748-1 (Q27-L559)	≥95%

Related Diseases

Diseases

Alias

Alveolar Echinococcosis

Echinococcus Multilocularis Infection	Echinococcosis
Alveolococcosis	Multilocular Hydatid
Small Fox Tapeworm

Cystic Echinococcosis

Echinococcus Granulosus Infection	Echinococcus Granulosus Infection Of Lung
Echinococcus Granulosus	Echinococcus Granulosus Infection Of Thyroid
Echinococcus Granulosus Infectious Disease	Echinococcus Granulosus Infectious Disease Of Liver
Echinococcus Granulosus Infectious Disease Of Thyroid	Liver Echinococcus Granulosus
Lung Echinococcus Granulosus	Thyroid Echinococcus Granulosus
Unilocular Echinococcosis	Unilocular Hydatid Disease
Hydatid Disease	Hydatidosis
Echinococcosis

North American Indian Childhood Cirrhosis

NAIC	Hereditary North American Indian Childhood Cirrhosis
Cirrhosis, North American Indian Childhood Type	Cirrhosis, Childhood, North American Indian

Large Intestine Adenoma

Adenoma Of Large Intestine

Taeniasis

Beef Tapeworm Infection	Infection By Taeniarhynchus Saginatus
Taenia Saginata Infectious Disease	Taenia Saginata Infection
Pork Tapeworm Infection	Armed Tapeworm Infection
Infection By Taenia Solium	Intestinal Taenia Solium Infection
Pork Tapeworm	Taenia Solium Taeniasis
Adult Pork Tapeworm Infection	Adult Pork Tapeworm
Beef Tapeworm	Infection By Taenia Saginata
Unarmed Tapeworm Infection	Taenia Saginata Taeniasis
Infection Due To Adult Tapeworm Taenia Saginata	Mediocanellata Taenia Infection
Infestation By Taenia Saginata	Infestation By Taenia Mediocanellata

Echinococcosis

Hydatidosis	Echinococcal Disease
Echinococcosis Of Liver	Hepatic Echinococcosis
Hydatid Disease	Liver Echinococcus
Pulmonary Echinococcosis	Hydatids
Echinococcosis, Hepatic	Echinococcosis, Pulmonary
Unilocular Echinococcosis	Echinococcus Disease
Echinococcus Granulosus Infection	Echinococcus Multilocularis Infection
Dog Tapeworm Infection	Echinococcus Granulosus Infestation
Echinococciasis	Cystic Echinococcosis

Parasitic Helminthiasis Infectious Disease

Helminthiasis	Intestinal Helminthiasis
Helminth Infection	Helminthosis
Worm Infection	Worm Infections
Helminth Infections	Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata
Parasitic Enteritis	Metazoal Dysentery
Intestinal Worms Nos

Cysticercosis

Neurocysticercosis	Submacular Cysticercosis
Intestinal Taenia Solium Infection	Pork Tapeworm Infection
Tapeworm Infection: Intestinal Taenia Solum	Tapeworm Infection: Pork
Tenia Solium Infectious Disease	Taeniasis
Tenia Solium Infection	Cysticerciasis Infection Due To Larval Form Of Taenia Solium

Cocaine Abuse

Cocaine-Related Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D2285	MOR-CES2		/	Unkown
HY-RS02544	CES2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CES2	RGD	RGD:1560889
Canis familiaris	CES2	VGNC	VGNC:39153
Bos taurus	CES2	VGNC	VGNC:27229
Macaca mulatta	CES2	VGNC	VGNC:71012
Felis catus	CES2	VGNC	VGNC:60796
Mus musculus	CES2	NCBI
Others	CES2	NCBI

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