CES2 - carboxylesterase 2 Gene

Also Known as iCE; CE-2; PCE-2; CES2A1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8824

About CES2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:66,934,471-66,945,096 (from NCBI)

This gene has 12 transcripts (splice variants), 721 orthologues and 13 paralogues. Biased expression in duodenum (RPKM 209.7), small intestine (RPKM 176.0) and 8 other tissues.

Summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and Cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

CES2 Products (6)

mRNA Protein Name
NM_001365405.1 NP_001352334.1 cocaine esterase isoform 1 precursor
NM_001365406.1 NP_001352335.1 cocaine esterase isoform 3
NM_001365407.1 NP_001352336.1 cocaine esterase isoform 3
NM_001365408.1 NP_001352337.1 cocaine esterase isoform 4
NM_003869.6 NP_003860.3 cocaine esterase isoform 1 precursor
NM_198061.3 NP_932327.2 cocaine esterase isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables carboxylesterase activity IDA
IDA: Inferred from direct assay
21049984 GOA
Biological Process GO Annotation Evidence References Source
involved in prostaglandin metabolic process IDA
IDA: Inferred from direct assay
21049984 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CES2 Protein Structure

COesterase

COesterase: Carboxylesterase family (81 - 602)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 623 a.a.
Protein Preferred Names Protein Names

cocaine esterase

  • carboxylesterase 2 (intestine, liver)

Recombinant CES2 Proteins

Cat. No. Product Name Accession Purity
HY-P76192 CES2/carboxylesterase 2 Protein, Human (HEK293, His) O00748-1 (Q27-L559) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Alveolar Echinococcosis

  • Echinococcus Multilocularis Infection

  • Echinococcosis

  • Alveolococcosis

  • Multilocular Hydatid

  • Small Fox Tapeworm
Cystic Echinococcosis

  • Echinococcus Granulosus Infection

  • Echinococcus Granulosus Infection Of Lung

  • Echinococcus Granulosus

  • Echinococcus Granulosus Infection Of Thyroid

  • Echinococcus Granulosus Infectious Disease

  • Echinococcus Granulosus Infectious Disease Of Liver

  • Echinococcus Granulosus Infectious Disease Of Thyroid

  • Liver Echinococcus Granulosus

  • Lung Echinococcus Granulosus

  • Thyroid Echinococcus Granulosus

  • Unilocular Echinococcosis

  • Unilocular Hydatid Disease

  • Hydatid Disease

  • Hydatidosis

  • Echinococcosis
North American Indian Childhood Cirrhosis

  • NAIC

  • Hereditary North American Indian Childhood Cirrhosis

  • Cirrhosis, North American Indian Childhood Type

  • Cirrhosis, Childhood, North American Indian
Large Intestine Adenoma

  • Adenoma Of Large Intestine
Taeniasis

  • Beef Tapeworm Infection

  • Infection By Taeniarhynchus Saginatus

  • Taenia Saginata Infectious Disease

  • Taenia Saginata Infection

  • Pork Tapeworm Infection

  • Armed Tapeworm Infection

  • Infection By Taenia Solium

  • Intestinal Taenia Solium Infection

  • Pork Tapeworm

  • Taenia Solium Taeniasis

  • Adult Pork Tapeworm Infection

  • Adult Pork Tapeworm

  • Beef Tapeworm

  • Infection By Taenia Saginata

  • Unarmed Tapeworm Infection

  • Taenia Saginata Taeniasis

  • Infection Due To Adult Tapeworm Taenia Saginata

  • Mediocanellata Taenia Infection

  • Infestation By Taenia Saginata

  • Infestation By Taenia Mediocanellata
Echinococcosis

  • Hydatidosis

  • Echinococcal Disease

  • Echinococcosis Of Liver

  • Hepatic Echinococcosis

  • Hydatid Disease

  • Liver Echinococcus

  • Pulmonary Echinococcosis

  • Hydatids

  • Echinococcosis, Hepatic

  • Echinococcosis, Pulmonary

  • Unilocular Echinococcosis

  • Echinococcus Disease

  • Echinococcus Granulosus Infection

  • Echinococcus Multilocularis Infection

  • Dog Tapeworm Infection

  • Echinococcus Granulosus Infestation

  • Echinococciasis

  • Cystic Echinococcosis
Parasitic Helminthiasis Infectious Disease

  • Helminthiasis

  • Intestinal Helminthiasis

  • Helminth Infection

  • Helminthosis

  • Worm Infection

  • Worm Infections

  • Helminth Infections

  • Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata

  • Parasitic Enteritis

  • Metazoal Dysentery

  • Intestinal Worms Nos
Cysticercosis

  • Neurocysticercosis

  • Submacular Cysticercosis

  • Intestinal Taenia Solium Infection

  • Pork Tapeworm Infection

  • Tapeworm Infection: Intestinal Taenia Solum

  • Tapeworm Infection: Pork

  • Tenia Solium Infectious Disease

  • Taeniasis

  • Tenia Solium Infection

  • Cysticerciasis Infection Due To Larval Form Of Taenia Solium
Cocaine Abuse

  • Cocaine-Related Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N1951 Miltirone Inhibitor 99.54% Unkown
HY-155181 CES2-IN-1 Inhibitor 99.93% Unkown
HY-173267 CES2A-IN-2 Inhibitor 99.16% Unkown
HY-N0855 Alisol G Inhibitor 98.13% Unkown
HY-176465 CES2A-IN-3 Inhibitor / Unkown
HY-184061 Carboxylesterase 2-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CES2 RGD RGD:1560889
Canis familiaris CES2 VGNC VGNC:39153
Bos taurus CES2 VGNC VGNC:27229
Macaca mulatta CES2 VGNC VGNC:71012
Felis catus CES2 VGNC VGNC:60796
Others CES2 NCBI