NEURL1 - neuralized E3 ubiquitin protein ligase 1 Gene

Also Known as neu; NEUR1; NEURL; RNF67; neu-1; bA416N2.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9148

About NEURL1

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,493,705-103,592,546 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 3 paralogues. Broad expression in brain (RPKM 4.6), colon (RPKM 2.4) and 15 other tissues.

Summary

Predicted to enable translation factor activity, non-nucleic acid binding and ubiquitin protein Ligase activity. Involved in negative regulation of Notch signaling pathway; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

NEURL1 Products (1)

mRNA Protein Name
NM_004210.5 NP_004201.3 E3 ubiquitin-protein ligase NEURL1

NEURL1 Protein Structure

Neuralized

Neuralized: Neuralized (62 - 130)

Neuralized

Neuralized: Neuralized (294 - 362)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (519 - 567)

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  • 574 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase NEURL1

  • RING finger protein 67

NEURL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NEURL1 O76050 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Malignant Astrocytoma

  • Astrocytic Tumor

  • Astrocytoma Of Brain

  • Astrocytoma Of Cerebrum

  • Astroglioma

  • Cerebral Astrocytoma

  • Astrocytoma
Medulloblastoma

  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Medulloblastoma Predisposition Syndrome

  • Medulloblastoma, Somatic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site
Syndromic X-Linked Intellectual Disability Siderius Type

  • Mrxssd

  • Siderius-Hamel Syndrome

  • Siderius X-Linked Mental Retardation Syndrome
Spondylocostal Dysostosis 1, Autosomal Recessive

  • Jarcho-Levin Syndrome

  • SCDO1

  • Vertebral Anomalies

  • Spondylothoracic Dysplasia

  • Costovertebral Dysplasia

  • Spondylothoracic Dysostosis

  • Spondylocostal Dysostosis 1

  • Autosomal Recessive Spondylocostal Dysostosis 1

  • Spondylocostal Dysostosis, Autosomal Recessive, 1

  • Doid:0112365

  • Dysostosis, Spondylocostal, Autosomal Recessive, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182008 NEURL1B-IN-1 / Unkown
HY-RS09219 NEURL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09220 NEURL1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NEURL1 MGD MGI:1334263
Macaca mulatta NEURL1 VGNC VGNC:75319
Rattus norvegicus NEURL1 RGD RGD:1307021
Canis familiaris NEURL1 VGNC VGNC:43750
Felis catus NEURL1 VGNC VGNC:68463
Bos taurus NEURL1 VGNC VGNC:32013
Others NEURL1 NCBI