RAB11B - RAB11B, member RAS oncogene family Gene

Also Known as H-YPT3; NDAGSCW

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9230

About RAB11B

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,390,360-8,404,434 (from NCBI)

This gene has 5 transcripts (splice variants), 115 orthologues, 68 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 36.5), thyroid (RPKM 36.2) and 25 other tissues.

Summary

The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

RAB11B Products (1)

mRNA	Protein	Name
NM_004218.4	NP_004209.2	ras-related protein Rab-11B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GDP binding	IDA IDA: Inferred from direct assay	16545962	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	16545962	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	16545962	GOA
enables myosin V binding	IPI IPI: Inferred from physical interaction	24006491	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20717956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid-beta clearance by transcytosis	IGI IGI: Inferred from genetic interaction	26005850	GOA
involved in cellular response to acidic pH	IDA IDA: Inferred from direct assay	20717956	GOA
involved in constitutive secretory pathway	IMP IMP: Inferred from mutant phenotype	14627637	GOA
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	19244346	GOA
involved in establishment of protein localization to membrane	IMP IMP: Inferred from mutant phenotype	24006491	GOA
involved in regulation of monoatomic anion transport	IMP IMP: Inferred from mutant phenotype	19244346	GOA
involved in regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	20717956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	21255211	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB11B Protein Structure

Ras

0
100
200
218 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-11B	GTP-binding protein YPT3

RAB11B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB11B	Q15907	RAB11FIP2	Homo sapiens	Q7L804	Anti Tag CoIP	28514442
Intra	RAB11B	Q15907	RAB11FIP2	Homo sapiens	Q7L804	Anti Tag CoIP	33961781
Intra	RAB11B	Q15907	RAB11FIP2	Homo sapiens	Q7L804	Validated Y2H	32296183
Intra	RAB11B	Q15907	RAB11FIP2	Homo sapiens	Q7L804	Anti Tag CoIP	35271311
Intra	RAB11B	Q15907	MYO5B	Homo sapiens	Q9ULV0-2	Validated Y2H	32296183
Intra	RAB11B	Q15907	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	RAB11B	Q15907	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RAB11B	Q15907	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RAB11B	Q15907	TBC1D14	Homo sapiens	Q9P2M4	Anti Tag CoIP	22613832
Intra	RAB11B	Q15907	TBC1D14	Homo sapiens	Q9P2M4	Y2H	22613832
Intra	RAB11B	Q15907	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	RAB11B	Q15907	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	RAB11B	Q15907	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	RAB11B	Q15907	SH3BP5L	Homo sapiens	Q7L8J4	Anti Tag CoIP	33961781
Intra	RAB11B	Q15907	SH3BP5L	Homo sapiens	Q7L8J4	Y2H Array	32296183
Intra	RAB11B	Q15907	SH3BP5L	Homo sapiens	Q7L8J4	Y2H Prey Pooling	32296183
Intra	RAB11B	Q15907	SH3BP5L	Homo sapiens	Q7L8J4	Anti Tag CoIP	28514442
Intra	RAB11B	Q15907	SH3BP5L	Homo sapiens	Q7L8J4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAB11B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74610	RAB11B Protein, Human (HEK293, His)	Q15907-1 (G2-C215)	≥ 95%, as determined by reducing SDS-PAGE.

RAB11B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86102	RB11 Antibody (YA5794)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Ataxic Gait, Absent Speech, And Decreased Cortical White Matter	NDAGSCW Neurodevelopmental Disorder With Ataxic Gait, Absent Speech, Decreased Cortical White Matter
Esophagus Sarcoma	Esophageal Sarcoma
Hypotrichosis 3	HYPT3 Hypotrichosis Simplex Of The Scalp 2 Htss2 Hypotrichosis, Type 3
Rectum Adenocarcinoma	Rectal Adenocarcinoma Adenocarcinoma Of Rectum
Rectal Benign Neoplasm	Neoplasm Of Rectum Rectal Tumor Rectum Neoplasm Neoplasm Of The Rectum Rectal Neoplasms Primary Rectal Cancer Rectal Ampulla Cancer Cancer Of The Rectum Carcinoma Of Rectum Primary Malignant Neoplasm Of Rectum Rectal Cancer Rectal Carcinoma
Rectum Cancer	Malignant Neoplasm Of Rectum Rectal Cancer Cancer Of Rectum Carcinoma Of Rectum Carcinoma Of The Rectum Malignant Rectal Tumor Malignant Rectum Tumor Malignant Tumor Of Rectum Rectal Carcinoma Rectal Cancers Cancer, Rectal
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11516	RAB11B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11567	RAB43 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19809	Rab11b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26305	Rab11b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAB11B	VGNC	VGNC:81518
Mus musculus	RAB11B	MGD	MGI:99425
Felis catus	RAB11B	VGNC	VGNC:97580
Canis familiaris	RAB11B	VGNC	VGNC:45249
Rattus norvegicus	RAB11B	RGD	RGD:68369
Bos taurus	RAB11B	VGNC	VGNC:33615
Others	RAB11B	NCBI