TBC1D14 - TBC1 domain family member 14 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57533

Summary

Enables protein kinase binding activity. Involved in negative regulation of autophagy; recycling endosome to Golgi transport; and regulation of autophagosome assembly. Located in Golgi apparatus; autophagosome; and recycling endosome. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in kidney (RPKM 20.3), brain (RPKM 18.5) and 25 other tissues.

TBC1D14 Products (5)

mRNA Protein Name
NM_001113361.2 NP_001106832.1 TBC1 domain family member 14 isoform a
NM_001113363.2 NP_001106834.1 TBC1 domain family member 14 isoform b
NM_001286805.2 NP_001273734.1 TBC1 domain family member 14 isoform c
NM_001330638.2 NP_001317567.1 TBC1 domain family member 14 isoform d
NM_020773.3 NP_065824.2 TBC1 domain family member 14 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
22613832 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
22613832 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
22613832 GOA
involved in recycling endosome to Golgi transport IMP
IMP: Inferred from mutant phenotype
17562788 GOA
involved in regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
22613832 GOA
NOT involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
17646400 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in autophagosome IDA
IDA: Inferred from direct assay
22613832 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
17562788 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBC1D14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TBC1D14 Q9P2M4 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra
TBC1D14 Q9P2M4 NXF1 Homo sapiens Q9UBU9
Y2H Array
32296183
Intra
TBC1D14 Q9P2M4 ULK1 Homo sapiens O75385
Anti Tag CoIP
22613832
Intra
TBC1D14 Q9P2M4 ULK1 Homo sapiens O75385
IF
22613832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14230 TBC1D1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14232 TBC1D15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14233 TBC1D16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14238 TBC1D24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14244 TBC1D4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22049 Tbc1d16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28567 Tbc1d16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown