MOB1B - MOB kinase activator 1B Gene

Also Known as MATS2; MOB4A; MOBKL1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92597

About MOB1B

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,901,851-70,988,168 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 6 paralogues. Ubiquitous expression in kidney (RPKM 9.7), bone marrow (RPKM 8.6) and 25 other tissues.

Summary

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

MOB1B Products (3)

mRNA Protein Name
NM_001244766.2 NP_001231695.1 MOB kinase activator 1B isoform 1
NM_001244767.2 NP_001231696.1 MOB kinase activator 1B isoform 3
NM_173468.4 NP_775739.1 MOB kinase activator 1B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinase activator activity IDA
IDA: Inferred from direct assay
15197186 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
15197186 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19739119 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
18328708 GOA
Biological Process GO Annotation Evidence References Source
involved in hippo signaling IDA
IDA: Inferred from direct assay
18328708 GOA
involved in regulation of protein autophosphorylation IDA
IDA: Inferred from direct assay
15197186 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
18328708 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
15067004 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15067004 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOB1B Protein Structure

Mob1_phocein

Mob1_phocein: Mob1/phocein family (30 - 205)

  • 0
  • 100
  • 200
  • 216 a.a.
Protein Preferred Names Protein Names

MOB kinase activator 1B

  • MOB1 Mps One Binder homolog B

MOB1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MOB1B Q7L9L4 LATS2 Homo sapiens Q9NRM7
Anti Tag CoIP
33961781
Intra
MOB1B Q7L9L4 LATS2 Homo sapiens Q9NRM7
Anti Tag CoIP
28514442
Intra
MOB1B Q7L9L4 LATS2 Homo sapiens Q9NRM7
BioID
24255178
Intra
MOB1B Q7L9L4 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
25416956
Intra
MOB1B Q7L9L4 STK4 Homo sapiens Q13043
Anti Tag CoIP
24255178
Intra
MOB1B Q7L9L4 STK4 Homo sapiens Q13043
Protein Kinase Assay
22863277
Intra
MOB1B Q7L9L4 STK4 Homo sapiens Q13043
BioID
24255178
Intra
MOB1B Q7L9L4 LATS1 Homo sapiens O95835
Anti Tag CoIP
19739119
Intra
MOB1B Q7L9L4 LATS1 Homo sapiens O95835
Anti Tag CoIP
28514442
Intra
MOB1B Q7L9L4 LATS1 Homo sapiens O95835
BioID
24255178
Intra
MOB1B Q7L9L4 LATS1 Homo sapiens O95835
Anti Tag CoIP
33961781
Intra
MOB1B Q7L9L4 LATS1 Homo sapiens O95835
Anti Tag CoIP
24255178
Intra
MOB1B Q7L9L4 LATS1 Homo sapiens O95835
Anti Tag CoIP
24366813
Intra
MOB1B Q7L9L4 NT5C2 Homo sapiens P49902
Y2H Prey Pooling
25416956
Intra
MOB1B Q7L9L4 NT5C2 Homo sapiens P49902
Validated Y2H
25416956
Intra
MOB1B Q7L9L4 NT5C2 Homo sapiens P49902
Y2H Array
25416956
Intra
MOB1B Q7L9L4 STK3 Homo sapiens Q13188
BioID
24255178
Intra
MOB1B Q7L9L4 STK3 Homo sapiens Q13188
Anti Tag CoIP
24255178
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MOB1B Proteins

Cat. No. Product Name Accession Purity
HY-P77449 MOB4A/MOB1B Protein, Human (His) Q7L9L4-1 (M1-R216) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Sveinsson Chorioretinal Atrophy

  • SCRA

  • Atrophia Areata

  • Helicoid Peripapillary Chorioretinal Degeneration

  • Hpcd

  • Aa

  • Peripapillary Chorioretinal Degeneration, Icelandic Type

  • Helicoidal Peripapillary Chorioretinal Degeneration

  • Atrophy, Chorioretinal, Sveinsson
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08574 MOB1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19459 Mob1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25952 Mob1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MOB1B VGNC VGNC:43300
Macaca mulatta MOB1B VGNC VGNC:74863
Rattus norvegicus MOB1B RGD RGD:1305114
Mus musculus MOB1B MGD MGI:1915723
Felis catus MOB1B VGNC VGNC:63544
Bos taurus MOB1B VGNC VGNC:31542
Others MOB1B NCBI