GSTO1 - glutathione S-transferase omega 1 Gene
Also Known as P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21
Species: Homo sapiens
About GSTO1
This gene has 7 transcripts (splice variants), 254 orthologues and 14 paralogues. Ubiquitous expression in liver (RPKM 91.8), heart (RPKM 47.6) and 25 other tissues.
Summary
The protein encoded by this gene is an omega class Glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
GSTO1 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001191002.2 | NP_001177931.1 | glutathione S-transferase omega-1 isoform 2 |
| NM_001191003.2 | NP_001177932.1 | glutathione S-transferase omega-1 isoform 3 |
| NM_004832.3 | NP_004823.1 | glutathione S-transferase omega-1 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables glutathione dehydrogenase (ascorbate) activity |
IDA
IDA: Inferred from direct assay
|
11511179 | GOA |
| enables glutathione transferase activity |
IDA
IDA: Inferred from direct assay
|
11511179 | GOA |
| enables oxidoreductase activity |
IDA
IDA: Inferred from direct assay
|
11511179 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25277244 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in L-ascorbic acid metabolic process |
IDA
IDA: Inferred from direct assay
|
11511179 | GOA |
| involved in cellular response to arsenic-containing substance |
IDA
IDA: Inferred from direct assay
|
11511179 | GOA |
| involved in negative regulation of ryanodine-sensitive calcium-release channel activity |
IDA
IDA: Inferred from direct assay
|
11035031 | GOA |
| involved in positive regulation of ryanodine-sensitive calcium-release channel activity |
IDA
IDA: Inferred from direct assay
|
11035031 | GOA |
| involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
IDA
IDA: Inferred from direct assay
|
11035031 | GOA |
| involved in xenobiotic catabolic process |
IDA
IDA: Inferred from direct assay
|
12928150 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
11511179 | GOA |
GSTO1 Protein Structure
GST_N_3: Glutathione S-transferase, N-terminal domain (27 - 100)
GST_C: Glutathione S-transferase, C-terminal domain (131 - 209)
- 0
- 100
- 200
- 241 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
glutathione S-transferase omega-1 |
|
GSTO1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82350 | GSTO1 Antibody (YA2095) | WB, IHC-P, ICC/IF | Human, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Night Blindness, Congenital Stationary, Type 1a |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Alzheimer Disease, Familial, 1 |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | GSTO1 | VGNC | VGNC:62731 |
| Canis familiaris | GSTO1 | VGNC | VGNC:41536 |
| Mus musculus | GSTO1 | MGD | MGI:1342273 |
| Rattus norvegicus | GSTO1 | RGD | RGD:70952 |
| Others | GSTO1 | NCBI |