GSTO1 - glutathione S-transferase omega 1 Gene

Also Known as P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9446

About GSTO1

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:104,254,173-104,267,455 (from NCBI)

This gene has 7 transcripts (splice variants), 254 orthologues and 14 paralogues. Ubiquitous expression in liver (RPKM 91.8), heart (RPKM 47.6) and 25 other tissues.

Summary

The protein encoded by this gene is an omega class Glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GSTO1 Products (3)

mRNA Protein Name
NM_001191002.2 NP_001177931.1 glutathione S-transferase omega-1 isoform 2
NM_001191003.2 NP_001177932.1 glutathione S-transferase omega-1 isoform 3
NM_004832.3 NP_004823.1 glutathione S-transferase omega-1 isoform 1
Molecular Function GO Annotation Evidence References Source
enables glutathione dehydrogenase (ascorbate) activity IDA
IDA: Inferred from direct assay
11511179 GOA
enables glutathione transferase activity IDA
IDA: Inferred from direct assay
11511179 GOA
enables oxidoreductase activity IDA
IDA: Inferred from direct assay
11511179 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25277244 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11511179 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSTO1 Protein Structure

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (27 - 100)

GST_C

GST_C: Glutathione S-transferase, C-terminal domain (131 - 209)

  • 0
  • 100
  • 200
  • 241 a.a.
Protein Preferred Names Protein Names

glutathione S-transferase omega-1

  • MMA(V) reductase

GSTO1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82350 GSTO1 Antibody (YA2095) WB, IHC-P, ICC/IF Human, Rat

Related Diseases

Diseases Alias
Night Blindness, Congenital Stationary, Type 1a
  • Congenital Stationary Night Blindness 1a

  • CSNB1A

  • Hemeralopia-Myopia

  • Myopia-Night Blindness

  • Night Blindness, Congenital Stationary , 1a, X-Linked

  • Congenital Stationary Night Blindness With Myopia

  • Csnb, Complete, X-Linked

  • Night Blindness, Congenital Stationary, With Myopia

  • Nbm1

  • Complete Csnb X-Linked

  • Congenital Stationary Night Blindness 1a X-Linked

  • Nbmi

  • Night Blindness, Congenital Stationary, 1a

  • Complete X-Linked Csnb

  • Nyctalopia

  • Xlcsnb

  • X-Linked Congenital Stationary Night Blindness

  • Blindness, Night, Stationary, Congenital, Type 1a

  • Night Blindness

  • X-Linked Csnb

  • Night Blindness, Congenital Stationary, Type 2a

Parkinson Disease, Late-Onset
  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease

Alzheimer Disease, Familial, 1
  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus GSTO1 VGNC VGNC:62731
Canis familiaris GSTO1 VGNC VGNC:41536
Mus musculus GSTO1 MGD MGI:1342273
Rattus norvegicus GSTO1 RGD RGD:70952
Others GSTO1 NCBI