PHF14 - PHD finger protein 14 Gene

Homo sapiens

Gene ID: 9678 | Gene type: protein coding

About PHF14

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:10,973,872-11,169,618 (from NCBI)

This gene has 16 transcripts (splice variants), 210 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 4.6), endometrium (RPKM 2.7) and 25 other tissues.

Summary

Predicted to enable histone binding activity. Predicted to be involved in histone H3-K14 acetylation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including lung alveolus development; negative regulation of mesenchymal cell proliferation involved in lung development; and negative regulation of platelet-derived growth factor receptor-alpha signaling pathway. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

PHF14 Products(2)

mRNA	Protein	Name
NM_001007157.2	NP_001007158.1	PHD finger protein 14 isoform 1
NM_014660.4	NP_055475.2	PHD finger protein 14 isoform 2

PHF14 Protein Structure

PHD

zf-HC5HC2H_2

PHD

0
200
400
600
800
888 a.a.

Protein Preferred Names

Protein Names

PHD finger protein 14

Related Diseases

Diseases

Alias

Ceroid Lipofuscinosis, Neuronal, 9

Neuronal Ceroid Lipofuscinosis 9	CLN9
Cln 9	Cln9 Disease

Dandy-Walker Syndrome

Dandy-Walker Malformation	DWS
Atresia Of Foramina Of Magendie And Luschka	Dandy-Walker Complex
Dandy-Walker Cyst	Dandy-Walker Deformity
Dandy Walker Cyst	Dw Complex
Dandy-Walker Syndrome Or Malformation	Dandy-Walker Variant
Mega Cisterna Magna	Dwm
Hydrocephalus, Internal, Dandy-Walker Type	Hydrocephalus, Noncommunicating, Dandy-Walker Type
Luschka-Magendie Foramina Atresia	Isolated Dandy-Walker Malformation
Mega-Cisterna Magna	Dandy Walker Variant
Atresia Of Foramen Of Luschka	Atresia Of Foramen Of Magendie
Congenital Blockage Of Foramen Magendie

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10418	PHF14 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PHF14	RGD	RGD:1563764
Mus musculus	PHF14	MGD	MGI:1923539
Canis familiaris	PHF14	VGNC	VGNC:44483
Macaca mulatta	PHF14	VGNC	VGNC:75847
Felis catus	PHF14	VGNC	VGNC:64139
Bos taurus	PHF14	VGNC	VGNC:32816

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