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PHF14 - PHD finger protein 14 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9678

About PHF14

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:10,973,872-11,169,618 (from NCBI)

This gene has 16 transcripts (splice variants), 210 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 4.6), endometrium (RPKM 2.7) and 25 other tissues.

Summary

Predicted to enable histone binding activity. Predicted to be involved in histone H3-K14 acetylation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including lung alveolus development; negative regulation of mesenchymal cell proliferation involved in lung development; and negative regulation of platelet-derived growth factor receptor-alpha signaling pathway. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

PHF14 Products (2)

mRNA	Protein	Name
NM_001007157.2	NP_001007158.1	PHD finger protein 14 isoform 1
NM_014660.4	NP_055475.2	PHD finger protein 14 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone binding	IDA IDA: Inferred from direct assay	23688586	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28160558	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	23688586	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23688586	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23688586	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF14 Protein Structure

PHD

zf-HC5HC2H_2

PHD

0
200
400
600
800
888 a.a.

Protein Preferred Names	Protein Names
PHD finger protein 14

PHF14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PHF14	O94880	KIF4A	Homo sapiens	O95239	Anti Bait CoIP	28160558

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ceroid Lipofuscinosis, Neuronal, 9	Neuronal Ceroid Lipofuscinosis 9 CLN9 Cln 9 Cln9 Disease
Dandy-Walker Syndrome	Dandy-Walker Malformation DWS Atresia Of Foramina Of Magendie And Luschka Dandy-Walker Complex Dandy-Walker Cyst Dandy-Walker Deformity Dandy Walker Cyst Dw Complex Dandy-Walker Syndrome Or Malformation Dandy-Walker Variant Mega Cisterna Magna Dwm Hydrocephalus, Internal, Dandy-Walker Type Hydrocephalus, Noncommunicating, Dandy-Walker Type Luschka-Magendie Foramina Atresia Isolated Dandy-Walker Malformation Mega-Cisterna Magna Dandy Walker Variant Atresia Of Foramen Of Luschka Atresia Of Foramen Of Magendie Congenital Blockage Of Foramen Magendie

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10418	PHF14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PHF14	RGD	RGD:1563764
Mus musculus	PHF14	MGD	MGI:1923539
Canis familiaris	PHF14	VGNC	VGNC:44483
Macaca mulatta	PHF14	VGNC	VGNC:75847
Felis catus	PHF14	VGNC	VGNC:64139
Bos taurus	PHF14	VGNC	VGNC:32816
Others	PHF14	NCBI