KIF4A - kinesin family member 4A Gene

Also Known as KIF4; KIF4G1; MRX100; XLID100

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 24137

About KIF4A

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,290,104-70,420,886 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues, 41 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 4.3), lymph node (RPKM 2.9) and 14 other tissues.

Summary

This gene encodes a member of the Kinesin 4 subfamily of Kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during Mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]

KIF4A Products (1)

mRNA	Protein	Name
NM_012310.5	NP_036442.3	chromosome-associated kinesin KIF4A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16431929	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	15843429	GOA
involved in mitotic spindle midzone assembly	IMP IMP: Inferred from mutant phenotype	15843429	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in midbody	IDA IDA: Inferred from direct assay	15166316	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF4A Protein Structure

Kinesin

0
200
400
600
800
1000
1232 a.a.

Protein Preferred Names	Protein Names
chromosome-associated kinesin KIF4A	chromokinesin-A

KIF4A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIF4A	O95239	PHF14	Homo sapiens	O94880-1	Anti Bait CoIP	28160558
Intra	KIF4A	O95239	PHF14	Homo sapiens	O94880	Anti Bait CoIP	28160558
Intra	KIF4A	O95239	PHF14	Homo sapiens	O94880	Confocal	28160558

Cross: Cross-species interaction Intra: Intraspecies interaction

KIF4A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82908	KIF4A Antibody (YA2653)	WB, FC	Human, Mouse

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked 100	XLID100 Mental Retardation, X-Linked 100 Mrx100 Mental Retardation, X-Linked, Type 100
Multicystic Dysplastic Kidney	Multicystic Renal Dysplasia Multicystic Kidney Dysplasia Mcdk Multiple Congenital Cysts Of Kidney Developmental Multicystic Kidney
Hydrocephalus, Congenital, 1	Hydrocephaly Ventriculomegaly Hydrocephalus, Nonsyndromic, Autosomal Recessive 1 HYC1 Congenital Non-Communicating Hydrocephalus Hydrocephalus, Nonsyndromic, Autosomal Recessive 1, Formerly Congenital Obstructive Hydrocephalus Hydrocephalus, Non-Syndromic, Autosomal Recessive 1 Hydrocephalus
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Charcot-Marie-Tooth Disease, Axonal, Type 2dd	CMT2DD Charcot-Marie-Tooth Neuropathy, Type 2dd Charcot-Marie-Tooth Disease Type 2dd Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Atp1a1-Related Cmt2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd Charcot-Marie-Tooth Disease 2dd
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07288	KIF4A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181694	SeSA-HCPT		/	Unkown
HY-RS26550	Kif4a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KIF4A	VGNC	VGNC:103830
Rattus norvegicus	KIF4A	RGD	RGD:620526
Mus musculus	KIF4A	MGD	MGI:108389
Others	KIF4A	NCBI