OXSR1 - oxidative stress responsive kinase 1 Gene

Also Known as OSR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9943

About OXSR1

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,164,063-38,255,484 (from NCBI)

This gene has 6 transcripts (splice variants), 98 orthologues and 35 paralogues. Ubiquitous expression in esophagus (RPKM 13.6), bone marrow (RPKM 11.2) and 25 other tissues.

Summary

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin Cytoskeleton. [provided by RefSeq, Jul 2008]

OXSR1 Products (1)

mRNA	Protein	Name
NM_005109.3	NP_005100.1	serine/threonine-protein kinase OSR1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	14707132	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16832045	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	14707132	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16669787	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16669787	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14707132	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	16669787	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell volume homeostasis	IDA IDA: Inferred from direct assay	36318922	GOA
involved in cellular hyperosmotic response	IDA IDA: Inferred from direct assay	36318922	GOA
involved in cellular response to chemokine	IMP IMP: Inferred from mutant phenotype	27400149	GOA
involved in chemokine (C-X-C motif) ligand 12 signaling pathway	IMP IMP: Inferred from mutant phenotype	27400149	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	14707132	GOA
involved in osmosensory signaling pathway	IMP IMP: Inferred from mutant phenotype	16669787	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	24393035	GOA
involved in peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	16669787	GOA
involved in positive regulation of T cell chemotaxis	IMP IMP: Inferred from mutant phenotype	27400149	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	22052202	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14707132	GOA
involved in renal sodium ion absorption	IDA IDA: Inferred from direct assay	18270262	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	16669787	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	22989884	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OXSR1 Protein Structure

Pkinase

OSR1_C

0
100
200
300
400
500
527 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase OSR1	oxidative stress responsive 1

OXSR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OXSR1	O95747	RELL2	Homo sapiens	Q8NC24	Y2H Prey Pooling	25416956
Intra	OXSR1	O95747	RELL2	Homo sapiens	Q8NC24	Validated Y2H	25416956
Intra	OXSR1	O95747	RELL2	Homo sapiens	Q8NC24	Validated Y2H	32296183
Intra	OXSR1	O95747	CAB39	Homo sapiens	Q9Y376	SPR	21423148
Intra	OXSR1	O95747	WNK1	Homo sapiens	Q9H4A3	Protein Kinase Assay	16832045
Intra	OXSR1	O95747	WNK1	Homo sapiens	Q9H4A3	Anti Bait CoIP	16832045
Intra	OXSR1	O95747	WNK1	Homo sapiens	Q9H4A3	Y2H	16832045
Intra	OXSR1	O95747	WNK1	Homo sapiens	Q9H4A3	Phage Display	35044719
Intra	OXSR1	O95747	WNK1	Homo sapiens	Q9H4A3	Anti Tag CoIP	35271311
Intra	OXSR1	O95747	WNK4	Homo sapiens	Q96J92	SPR	17721439
Intra	OXSR1	O95747	WNK4	Homo sapiens	Q96J92	Phage Display	35044719
Intra	OXSR1	O95747	WNK2	Homo sapiens	Q9Y3S1	Phage Display	35044719
Intra	OXSR1	O95747	WNK2	Homo sapiens	Q9Y3S1	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OXSR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77119	OXSR1 Protein, Human (sf9, GST)	O95747 (M1-S527)	≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Hypomagnesemia 4, Renal	Renal Hypomagnesemia 4 HOMG4 Hypomagnesemia, Renal, Normocalciuric Hypomagnesemia 4 Renal Hypomagnesemia Normocalciuric Hypomagnesemia, Type 4, Renal
Arthrogryposis, Distal, Type 3	Gordon Syndrome DA3 Distal Arthrogryposis Type 3 Arthrogryposis Multiplex Congenita, Distal, Type Iia Camptodactyly, Cleft Palate, And Clubfoot Camptodactyly-Cleft Palate-Clubfoot Syndrome Distal Arthrogryposis Multiplex Congenita Type Iia Arthrogryposis Distal Type 3 Distal Arthrogryposis Type Iia Arthrogryposis, Distal, 3 Pseudohypoaldosteronism, Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09892	OXSR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19467	Oxsr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25960	Oxsr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	OXSR1	RGD	RGD:1310466
Felis catus	OXSR1	VGNC	VGNC:97546
Macaca mulatta	OXSR1	VGNC	VGNC:81491
Mus musculus	OXSR1	MGD	MGI:1917378
Canis familiaris	OXSR1	VGNC	VGNC:44205
Bos taurus	OXSR1	VGNC	VGNC:32514
Others	OXSR1	NCBI