Glucagon receptor antagonist-7
Glucagon receptor antagonist-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC50 of 181 nM. Glucagon receptor antagonist-7 activates glucagon-stimulated adenylyl cyclase with a KDB of 81 nM in CHO cell. Glucagon receptor antagonist-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels.
For research use only. We do not sell to patients.
- CAS No.: 438618-32-7
- Formula: C20H30N2OS
- Molecular Weight:346.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
IC50: human glucagon receptor (hGCGR) (181 nM)
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
129 nM
Compound: 2
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Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cells
Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cells
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[PMID: 15713396] |
| CHO | IC50 |
181 nM
Compound: 2
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Inhibitory concentration towards binding of [125I]glucagon to the human glucagon receptor expressed in CHO cells
Inhibitory concentration towards binding of [125I]glucagon to the human glucagon receptor expressed in CHO cells
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[PMID: 15713396] |
Chemical Information
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CAS No. 438618-32-7
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Molecular Weight 346.53
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Formula C20H30N2OS
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SMILES
CCC(CC)C(NC1=C(C#N)C(CCC(C(C)(C)CC)C2)=C2S1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glucagon receptor antagonist-7 Related Classifications
HY-128103 Related Classifications
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