Glutamate-5-kinase-IN-1
Glutamate-5-kinase-IN-1 (compound 50) is a potent glutamate-5-kinase (G5K) inhibitor with an MIC (minimum inhibitory concentration) of 4.1 μM. Glutamate-5-kinase-IN-1 shows G5K inhibition by alters the ATP binding site architecture for enzyme recognition. Glutamate-5-kinase-IN-1 has the potential for the research of anti-TB agents.
For research use only. We do not sell to patients.
- CAS No.: 3033395-24-0
- Formula: C20H18N2O
- Molecular Weight:302.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
G5K[1]
Glutamate-5-kinase-IN-1 (compound 50) (40 μM) inhibits G5K activity with an I0.5 of 22.1 μM at 10 mM concentration of L-Glu and ATP[1].
Glutamate-5-kinase-IN-1 (5, 10, 20 μM) shows no relevant cytotoxicity in HepG2 cells[1].
Glutamate-5-kinase-IN-1 (120 μM) causes a substantial increase in the Kmapp for ATP at constant concentrations of L-Glu (150 mM, 300 mM and 600 mM) and ATP (10 mM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3033395-24-0
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Molecular Weight 302.37
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Formula C20H18N2O
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SMILES
COC1=CC=C2C3=C(NC=C3)C(CCC4=CC=CC=C4)=NC2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glutamate-5-kinase-IN-1 Related Classifications
HY-144381 Related Classifications
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