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Cat. No.: HY-141190

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Gly-Gly-Gly-PEG3-TCO

Name: Gly-Gly-Gly-PEG3-TCO
Brand: MedChemExpress
SKU: HY-141190
Price: 200.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Gly-Gly-Gly-PEG3-TCO is a 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Gly-Gly-Gly-PEG3-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

For research use only. We do not sell to patients.

Purity : 99.90%
CAS No.: 2353409-81-9
Formula: C₂₃H₄₁N₅O₈
Molecular Weight:515.60

Storage:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Gly-Gly-Gly-PEG3-TCO Chemical Structure

CAS No.: 2353409-81-9

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Gly-Gly-Gly-PEG3-TCO is a 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Gly-Gly-Gly-PEG3-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

All ADC Linkers Isoforms :

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2353409-81-9
Appearance Oil
Molecular Weight 515.60
Formula C₂₃H₄₁N₅O₈
Color Off-white to light yellow
SMILES

NCC(NCC(NCC(NCCOCCOCCOCCNC(OC1CC/C=C\CCC1)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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