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Cat. No.: HY-181447

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GPX4 (S)-9i

GPX4 (S)-9i is a GPX4 inhibitor and ferroptosis inducer, with its (R) enantiomer exhibiting stronger activity. GPX4 (S)-9i can be used for the study of fibrosarcoma.

For research use only. We do not sell to patients.

CAS No.: 3104351-76-7
Formula: C₂₉H₂₄N₄O₃S₂
Molecular Weight:540.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GPX4 (S)-9i Chemical Structure

CAS No.: 3104351-76-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

GPX4 (S)-9i is a GPX4 inhibitor and ferroptosis inducer, with its (R) enantiomer exhibiting stronger activity. GPX4 (S)-9i can be used for the study of fibrosarcoma^[1].

IC₅₀ & Target^[1]

GPX4

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	IC₅₀	0.012 μM Compound: (S)-9i	Cytotoxicity against human HT-1080 cells assessed as cell viability incubated for 24 hrs by CCK-8 assay Cytotoxicity against human HT-1080 cells assessed as cell viability incubated for 24 hrs by CCK-8 assay	[PMID: 39884957]

In Vitro

GPX4 (S)-9i (Compound (S)-9i) induces ferroptosis in HT1080 cells, with an IC₅₀ of 0.012 μM and a ferroptosis selectivity index of 976^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3104351-76-7
Molecular Weight 540.66
Formula C₂₉H₂₄N₄O₃S₂
SMILES

CC(C)(NC([C@@H](N(C(C1=CSC(C#C)=N1)=O)C2=CC=C(C3=CN=CO3)C=C2)C4=CSC5=CC=CC=C54)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gu S, et al. Development of a Highly Selective Ferroptosis Inducer Targeting GPX4 with 2-Ethynylthiazole-4-carboxamide as Electrophilic Warhead. J Med Chem. 2025;68(3):3309-3323. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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GPX4 (S)-9i

All Glutathione Peroxidase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GPX4 (S)-9i Related Classifications

HY-181447 Related Classifications