2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase Ferroptosis
  4. GPX4 (S)-9i

GPX4 (S)-9i is a GPX4 inhibitor and ferroptosis inducer, with its (R) enantiomer exhibiting stronger activity. GPX4 (S)-9i can be used for the study of fibrosarcoma.

For research use only. We do not sell to patients.

GPX4 (S)-9i

GPX4 (S)-9i Chemical Structure

CAS No. : 3104351-76-7

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GPX4 (S)-9i Related Antibodies

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Description

GPX4 (S)-9i is a GPX4 inhibitor and ferroptosis inducer, with its (R) enantiomer exhibiting stronger activity. GPX4 (S)-9i can be used for the study of fibrosarcoma[1].

IC50 & Target[1]

GPX4

 

Cellular Effect
Cell Line Type Value Description References
HT-1080 IC50
0.012 μM
Compound: (S)-9i
Cytotoxicity against human HT-1080 cells assessed as cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against human HT-1080 cells assessed as cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 39884957]
In Vitro

GPX4 (S)-9i (Compound (S)-9i) induces ferroptosis in HT1080 cells, with an IC50 of 0.012 μM and a ferroptosis selectivity index of 976[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GPX4 (S)-9i Related Antibodies
Molecular Weight

540.66

Formula

C29H24N4O3S2
CAS No.
SMILES

CC(C)(NC([C@@H](N(C(C1=CSC(C#C)=N1)=O)C2=CC=C(C3=CN=CO3)C=C2)C4=CSC5=CC=CC=C54)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GPX4 (S)-9i Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPX4 (S)-9i3104351-76-7Glutathione PeroxidaseFerroptosisHT1080 cellscancer cellsGPX4ferroptosisInhibitorinhibitorinhibit

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