2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GSK-3β inhibitor 10

GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease.

For research use only. We do not sell to patients.

GSK-3β inhibitor 10 Chemical Structure

GSK-3β inhibitor 10 Chemical Structure

CAS No. : 1198098-03-1

Size Price Stock Quantity
5 mg USD 120 In-stock
10 mg USD 195 In-stock
25 mg USD 390 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

GSK-3β inhibitor 10 Related Antibodies

Top Publications Citing Use of Products

View All GSK-3 Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease[1].

IC50 & Target[1]

GSK-3β

80.5 nM (IC50)

Molecular Weight

264.30

Formula

C12H12N2O3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC(C=C1/C=C2C(N=C(S/2)N)=O)=C(C=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (94.59 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7836 mL 18.9179 mL 37.8358 mL
5 mM 0.7567 mL 3.7836 mL 7.5672 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7836 mL 18.9179 mL 37.8358 mL 94.5895 mL
5 mM 0.7567 mL 3.7836 mL 7.5672 mL 18.9179 mL
10 mM 0.3784 mL 1.8918 mL 3.7836 mL 9.4589 mL
15 mM 0.2522 mL 1.2612 mL 2.5224 mL 6.3060 mL
20 mM 0.1892 mL 0.9459 mL 1.8918 mL 4.7295 mL
25 mM 0.1513 mL 0.7567 mL 1.5134 mL 3.7836 mL
30 mM 0.1261 mL 0.6306 mL 1.2612 mL 3.1530 mL
40 mM 0.0946 mL 0.4729 mL 0.9459 mL 2.3647 mL
50 mM 0.0757 mL 0.3784 mL 0.7567 mL 1.8918 mL
60 mM 0.0631 mL 0.3153 mL 0.6306 mL 1.5765 mL
80 mM 0.0473 mL 0.2365 mL 0.4729 mL 1.1824 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

GSK-3β inhibitor 10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-3β inhibitor 101198098-03-1GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3Alzheimer’s diseaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
GSK-3β inhibitor 10
Cat. No.:
HY-147134
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.