HBT-CUR
HBT-CUR is a lysosome-targeted and polarity-responsive tumor photosensitizer. HBT-CUR generates singlet oxygen under light irradiation. HBT-CUR induces photodynamic apoptosis through oxidative stress. As a polarity-sensitive NIR fluorescent probe, HBT-CUR distinguishes tumor cells and tissues from normal ones. HBT-CUR enables tumor-specific in vivo fluorescence imaging with rapid response and long-lasting duration. HBT-CUR is used for breast cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2894038-40-3
- Formula: C19H14BF2NO3S
- Molecular Weight:385.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
HBT-CUR (10 mM; 1 min) generates reactive oxygen species under LED light irradiation in a cell-free DCFH assay[1].
HBT-CUR has small calculated ΔEST values (0.07-0.27 eV) that accelerate ISC and promote efficient ROS generation[1].
HBT-CUR produces singlet oxygen, as confirmed by EPR spectroscopy[1].
HBT-CUR (5 μM; 48 h) exhibits low cytotoxicity and good biocompatibility across human cancer and normal cell lines[1].
HBT-CUR (5-10 μM; 20 min) enables specific imaging of lysosomal polarity in tumor cells and distinguishes them from normal cells based on polarity differences[1].
HBT-CUR (5 μM; 20 min) exerts a tumor cell-killing effect under LED irradiation in MCF-7 cells[1].
HBT-CUR (5 μM; 20 min) induces tumor cell apoptosis at the cellular level by generating singlet oxygen to mediate photodynamic activity in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:4T1, MCF-7, HepG2, MDA-MB-231, 786-o, HK-2, MCF-10A
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Concentration:5 μM
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Incubation Time:48 h
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Result:Maintained cell viability above 90% below 5 μM and over 80% at all time points up to 48 h at 5 μM.
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Cell Line:4T1, MCF-7, HepG2, MDA-MB-231, 786-o, HK-2, MCF-10A
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Concentration:10 μM; 5 μM
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Incubation Time:20 min
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Result:Achieved optimal imaging at 15-20 min with Pearson's R = 0.96 for lysosome co-localization; tumor cell lines exhibited intense red fluorescence while normal cell lines showed weak signals.
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Cell Line:MCF-7
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Concentration:5 μM
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Incubation Time:20 min
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Result:Induced extensive red fluorescence under LED irradiation, indicating cell death.
In Vivo
HBT-CUR (1 mM; intratumoral injection) combined with 300 mW/cm2 light irradiation for 20 min effectively inhibits MCF-7 tumor growth within 14 days by inducing tumor cell necrosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice (female, weighed about 20 g)[1]
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Dosage:1 mM
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Administration:Intratumoral injection
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Result:Reached maximum fluorescence intensity at approximately 10 min with a signal intensity ~10-fold higher than background fluorescence.
Sustained robust fluorescence emission for up to 6 h post-injection.
Exhibited intense fluorescence specifically in tumor tissues with a fluorescence intensity ~6-fold higher than that in normal tissues.
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Animal Model:Nude mice (female, weighed about 20 g)[1]
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Dosage:1 mM
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Administration:Intratumoral injection; followed by LED light irradiation (300 mW/cm2) for 20 min
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Result:Significantly reduced tumor volume after 14 days.
Body weight remained basically unchanged within 14 days.
Induced complete tumor cell necrosis with disappearing nuclei.
Chemical Information
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CAS No. 2894038-40-3
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Molecular Weight 385.19
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Formula C19H14BF2NO3S
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SMILES
F[B-]1(F)OC(C)=CC(/C=C/C2=C(O)C(C3=NC(C=CC=C4)=C4S3)=CC=C2)=[O+]1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HBT-CUR Related Classifications
HY-189294 Related Classifications
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