2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. HDAC8-IN-11

HDAC8-IN-11 is a ligand for target protein for pROTAC.

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HDAC8-IN-11

HDAC8-IN-11 Chemical Structure

CAS No. : 3035977-24-0

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HDAC8-IN-11 Related Antibodies

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Description

HDAC8-IN-11 is a ligand for target protein for pROTAC.

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 33.3 μM
Compound: 6
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
A549 IC50
> 33.3 μM
Compound: 6
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay
[PMID: 39089850]
HCT-116 IC50
> 33.3 μM
Compound: 6
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
HCT-116 IC50
> 33.3 μM
Compound: 6
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay
[PMID: 39089850]
Jurkat IC50
> 33.3 μM
Compound: 6
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
Jurkat IC50
> 33.3 μM
Compound: 6
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay
[PMID: 39089850]
THP-1 IC50
> 33.3 μM
Compound: 6
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
THP-1 IC50
> 33.3 μM
Compound: 6
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay
[PMID: 39089850]
Molecular Weight

291.39

Formula

C16H25N3O2
CAS No.
SMILES

O=C(C)NCC1=CC=C(C(NNCCCCCC)=O)C=C1
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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HDAC8-IN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC8-IN-113035977-24-0Ligands for Target Protein for PROTACTarget Protein-binding MoietyInhibitorinhibitorinhibit

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HY-163921
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