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Cat. No.: HY-151250

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HIV-1 protease-IN-7

HIV-1 protease-IN-7 (compound 16) is an orally active HIV-1 protease inhibitor (IC₅₀=3.52 nM, EC₅₀=37 nM).

For research use only. We do not sell to patients.

CAS No.: 2916441-36-4
Formula: C₆₈H₁₀₄N₁₀O₁₂S
Molecular Weight:1285.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HIV-1 protease-IN-7 Chemical Structure

CAS No.: 2916441-36-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

HIV-1 protease-IN-7 (compound 16) is an orally active HIV-1 protease inhibitor (IC₅₀=3.52 nM, EC₅₀=37 nM)^[1].

IC₅₀ & Target

HIV-1 protease^[1].

In Vivo

HIV-1 protease-IN-7 (2.57 mg/kg; p.o.; single) exhibits good plasma total clearance and oral bioavailability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats (8-week-old)^[1].
Dosage:

2.57 mg/kg (2 μM/kg)
Administration:

Oral administration; single.
Result:

1.19 Pharmacokinetic Parameters of HIV-1 protease-IN-7 in male Sprague-Dawley rats^[1].

metabolic stability rat/human (%) CL_tot (mL/min/kg) Vd_ss (L/kg) t_1/2 (h) F (%) serum fu(%)

PO (2.57 mg/kg) 63/23 8.2 1.9 3.9 3.3 0.1

Chemical Information

CAS No. 2916441-36-4
Molecular Weight 1285.68
Formula C₆₈H₁₀₄N₁₀O₁₂S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kusumoto Y, et al. Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization. ACS Medicinal Chemistry Letters, 2022.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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