pan-KRAS-IN-6
pan-KRAS-IN-6 (compound 12) is a potent pan KRAS inhibitor with IC50 values of 9.79 nM (Kras G12D) and 6.03 nM (Kras G12V).
For research use only. We do not sell to patients.
- CAS No.: 3033565-36-2
- Formula: C29H30ClF3N6O3S
- Molecular Weight:635.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
KRas G12D 9.79 nM (IC50) |
KRas G12V 6.03 nM (IC50) |
In Vitro
pan-KRAS-IN-6 (20 nM; 72 h) has a good inhibitory effect on the growth of ASPC-1 cells (IC50=8.8 μm)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:AsPC-1 and SW480 cell lines
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Concentration:20 nM
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Incubation Time:72 h
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Result:Inhibited the growth of AsPC-1 cell lines
Chemical Information
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CAS No. 3033565-36-2
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Molecular Weight 635.10
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Formula C29H30ClF3N6O3S
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SMILES
FC1=C(C2=C(N=C(N)S3)C3=C(F)C=C2)C(Cl)=CC4=C(N5CC(C)(O)COCC5)N=C(OC[C@@]6(CCC7)N7C[C@H](F)C6)N=C14
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
pan-KRAS-IN-6 Related Classifications
HY-162439 Related Classifications
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