Human enteropeptidase-IN-2 

Human enteropeptidase-IN-2 (compound 1c) is a highly potent enteropeptidase inhibitor. Human enteropeptidase-IN-2 can be used for anti-obesity research^[1].

IC_50(initial): 540 nM (enteropeptidase)^[1]
IC_50(app): 30 nM (enteropeptidase)^[1]

Human enteropeptidase-IN-2 (compound 1c) has inhibitory activity against enteropeptidase with IC_50(initial)* of 540 nM and IC_50(app)** of 30 nM^[1].
_{(*IC50(initial) refers to the inhibitory activity of human enteropeptidase after 6 min of incubation with the enzyme, substrate, and compound.
**IC50(app) refers to the apparent IC50 value after 120 min of incubation with the enzyme, substrate, and compound.)}

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

484.38

C₂₀H₁₉F₃N₄O₇

3031537-31-9

NC(NC1=CC=C(C=C1)C(OC2=CC=C(CC(NCC(O)=O)=O)C=C2)=O)=N.OC(C(F)(F)F)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ikeda Z, et al. Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity. J Med Chem. 2022 Jun 23;65(12):8456-8477.  [Content Brief]