2. Immunology/Inflammation
  3. STING
  4. IACS-8803

IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (IACS-8803 disodium and IACS-8803 diammonium) that retains the same biological activity.

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IACS-8803

IACS-8803 構造式

CAS 番号 : 2095690-70-1

容量 在庫状況
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IACS-8803 関連抗体

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製品説明

IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy[1].

IC50 & Target

STING[1]
体内実験

IACS-8803 shows a superior systemic anti-tumor response in the B16 murine model of melanoma[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

692.53

分子式

C20H23FN10O9P2S2
CAS 番号
Appearance

Solid

Color

White to yellow

SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](F)[C@H](O[P@@]4(S)=O)[C@@H](CO[P@](O[C@@H]5[C@H](O)[C@@H](CO4)O[C@H]5N(C=N6)C7=C6C(N)=NC=N7)(S)=O)O3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 15 mg/mL (21.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4440 mL 7.2199 mL 14.4398 mL
5 mM 0.2888 mL 1.4440 mL 2.8880 mL
10 mM 0.1444 mL 0.7220 mL 1.4440 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4440 mL 7.2199 mL 14.4398 mL 36.0995 mL
5 mM 0.2888 mL 1.4440 mL 2.8880 mL 7.2199 mL
10 mM 0.1444 mL 0.7220 mL 1.4440 mL 3.6100 mL
15 mM 0.0963 mL 0.4813 mL 0.9627 mL 2.4066 mL
20 mM 0.0722 mL 0.3610 mL 0.7220 mL 1.8050 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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IACS-8803 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IACS-88032095690-70-1IACS8803IACS 8803STINGStimulator of Interferon GenesTMEM173MITAERISMPYSantitumorefficacyB16murinemelanomaInhibitorinhibitorinhibit

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製品番号:
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