2. Membrane Transporter/Ion Channel
  3. CFTR
  4. IDOR-4

IDOR-4 is a type IV CFTR corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface.

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IDOR-4

IDOR-4 화학구조

CAS No. : 2839901-24-3

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

IDOR-4 Related Antibodies

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제품 설명

IDOR-4 is a type IV CFTR corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface[1].

In Vitro

IDOR-4 (0.1-1000 nM, 24 h) restores F508del-CFTR function (YFP quenching assay), indicated by the increased F508del-CFTR C-band expression in CFBE cells, reflecting the trafficking to the cell surface[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IDOR-4 Related Antibodies
분자량

916.95

화학식

C44H51F3N12O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C2N=CC=CC2=C3C(N[C@@H](CC(N([C@H](C(N([C@@H](C(N[C@@H](COC3=C1)CC4=CC=CC=C4)=O)CC5=NC(C(F)(F)F)=NO5)C)=O)CC(C)C)C)=O)C(NCCN6N=NC(C7CC7)=N6)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : ≥ 250 mg/mL (272.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0906 mL 5.4529 mL 10.9057 mL
5 mM 0.2181 mL 1.0906 mL 2.1811 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0906 mL 5.4529 mL 10.9057 mL 27.2643 mL
5 mM 0.2181 mL 1.0906 mL 2.1811 mL 5.4529 mL
10 mM 0.1091 mL 0.5453 mL 1.0906 mL 2.7264 mL
15 mM 0.0727 mL 0.3635 mL 0.7270 mL 1.8176 mL
20 mM 0.0545 mL 0.2726 mL 0.5453 mL 1.3632 mL
25 mM 0.0436 mL 0.2181 mL 0.4362 mL 1.0906 mL
30 mM 0.0364 mL 0.1818 mL 0.3635 mL 0.9088 mL
40 mM 0.0273 mL 0.1363 mL 0.2726 mL 0.6816 mL
50 mM 0.0218 mL 0.1091 mL 0.2181 mL 0.5453 mL
60 mM 0.0182 mL 0.0909 mL 0.1818 mL 0.4544 mL
80 mM 0.0136 mL 0.0682 mL 0.1363 mL 0.3408 mL
100 mM 0.0109 mL 0.0545 mL 0.1091 mL 0.2726 mL
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IDOR-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDOR-42839901-24-3IDOR4IDOR 4CFTRCystic fibrosis transmembrane conductance regulatorCFTR correctorCFTR traffickingInhibitorinhibitorinhibit

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상품명:
IDOR-4
Cat. No.:
HY-158002
수량:
MCE Japan Authorized Agent:

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