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Cat. No.: HY-189085

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IGF-1R-IN-6

IGF-1R-IN-6 is an IGF-1R inhibitor and a co-crystal ligand in the kinase structure of PDB 3EKK. IGF-1R-IN-6 occupies the kinase binding pocket. IGF-1R-IN-6 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 1186659-59-5
Formula: C₂₇H₂₇FN₈O₃
Molecular Weight:530.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IGF-1R-IN-6 Chemical Structure

CAS No.: 1186659-59-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

IGF-1R-IN-6 is an IGF-1R inhibitor and a co-crystal ligand in the kinase structure of PDB 3EKK. IGF-1R-IN-6 occupies the kinase binding pocket. IGF-1R-IN-6 can be used in cancer research^[1].

IC₅₀ & Target

^[1]

IGF-1R

In Vitro

IGF-1R-IN-6 (PDB 3EKK co-crystallized ligand) reproduces its co-crystal binding conformation after computational re-docking in the PDB 3EKK kinase structure, with an RMSD of 0.4795 and a docking score of -12.1398^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1186659-59-5
Molecular Weight 530.55
Formula C₂₇H₂₇FN₈O₃
SMILES

O=C(C1=C(NC2=C3C=CNC3=NC(NC4=CC5=C(C=C4OC)C=CN5C(CN(C)C)=O)=N2)C=CC=C1F)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Garg M, et al. Identification of new insulin growth factor receptor-1 (IGF-1R) inhibitors via exploring ATPas kinase domain of IGF-1R through virtual screening. Med Chem Res. 2017;26(1):205-219.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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