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Cat. No.: HY-129607

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A-65317

A-65317 is a primate-selective renin dipeptide inhibitor (IC₅₀ of 0.37 nM) with long hypotensive response.

For research use only. We do not sell to patients.

CAS No.: 122224-84-4
Formula: C₃₈H₅₈N₆O₉
Molecular Weight:742.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

A-65317 Chemical Structure

CAS No.: 122224-84-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

A-65317 is a primate-selective renin dipeptide inhibitor (IC₅₀ of 0.37 nM) with long hypotensive response^[1]^[2].

Chemical Information

CAS No. 122224-84-4
Molecular Weight 742.90
Formula C₃₈H₅₈N₆O₉
SMILES

O=C([C@@H](CC1=CNC=N1)NC([C@@H](CC(N(CCOCOCCOC)C)=O)CC2=CC=CC=C2)=O)N[C@H](C(O)[C@@H]3CN(C(O3)=O)CC)CC4CCCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. K M Verburg, et al. Effect of intrarenal renin inhibition on renal hemodynamics and excretory function. Am J Physiol. 1990 Jul;259(1 Pt 2):R7-14. [Content Brief]

[2]. Saul H. Rosenberg, et al. Renin Inhibitors. Integration of Pharmaceutical Discovery and Development Chapter pp 7-28.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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