TLCD1 - TLC domain containing 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116238

About TLCD1

This gene has 4 transcripts (splice variants), 196 orthologues and 5 paralogues. Ubiquitous expression in ovary (RPKM 8.5), lymph node (RPKM 6.1) and 25 other tissues.

Summary

Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TLCD1 Products (2)

mRNA Protein Name
NM_001160407.2 NP_001153879.1 TLC domain-containing protein 1 isoform 2
NM_138463.4 NP_612472.1 TLC domain-containing protein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in membrane assembly IMP
IMP: Inferred from mutant phenotype
30509349 GOA
involved in phospholipid homeostasis IMP
IMP: Inferred from mutant phenotype
30509349 GOA
involved in plasma membrane organization IMP
IMP: Inferred from mutant phenotype
30509349 GOA
involved in regulation of membrane lipid distribution IMP
IMP: Inferred from mutant phenotype
30509349 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
30509349 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLCD1 Protein Structure

TRAM_LAG1_CLN8

TRAM_LAG1_CLN8: TLC domain (44 - 227)

  • 0
  • 100
  • 200
  • 247 a.a.
Protein Preferred Names Protein Names

TLC domain-containing protein 1

  • calfacilitin

TLCD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TLCD1 Q96CP7 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
TLCD1 Q96CP7 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
TLCD1 Q96CP7 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
TLCD1 Q96CP7 FXYD3 Homo sapiens Q14802-3
Y2H Array
32296183
Intra
TLCD1 Q96CP7 FXYD3 Homo sapiens Q14802-3
Y2H Prey Pooling
32296183
Intra
TLCD1 Q96CP7 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
TLCD1 Q96CP7 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
TLCD1 Q96CP7 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
TLCD1 Q96CP7 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
TLCD1 Q96CP7 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
TLCD1 Q96CP7 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
TLCD1 Q96CP7 CD40 Homo sapiens P25942
Y2H Prey Pooling
32296183
Intra
TLCD1 Q96CP7 CD40 Homo sapiens P25942
Y2H Array
32296183
Intra
TLCD1 Q96CP7 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
TLCD1 Q96CP7 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
TLCD1 Q96CP7 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
TLCD1 Q96CP7 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
TLCD1 Q96CP7 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176431 TLCD1-IN-1 Inhibitor / Unkown
HY-RS14561 TLCD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TLCD1 VGNC VGNC:47393
Mus musculus TLCD1 MGD MGI:1915572
Felis catus TLCD1 VGNC VGNC:66206
Bos taurus TLCD1 VGNC VGNC:35887
Macaca mulatta TLCD1 VGNC VGNC:104665
Rattus norvegicus TLCD1 RGD RGD:1359195
Others TLCD1 NCBI