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Cat. No.: HY-176431

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TLCD1-IN-1

TLCD1-IN-1 (compound MB-4A) is a covalent TLCD1 inhibitor. TLCD1-IN-1 stereoselectively engages and inhibits TLCD1 in HepG2 cells.

For research use only. We do not sell to patients.

Formula: C₂₀H₁₉ClNO₅PS₂
Molecular Weight:483.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

TLCD1-IN-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

TLCD1-IN-1 (compound MB-4A) is a covalent TLCD1 inhibitor. TLCD1-IN-1 stereoselectively engages and inhibits TLCD1 in HepG2 cells^[1].

All Endogenous Metabolite Isoforms :

Chemical Information

Molecular Weight 483.93
Formula C₂₀H₁₉ClNO₅PS₂
SMILES

O=C(N1[C@H](COP2(SCCO2)=S)[C@@H](C3=CC=C(Cl)C=C3)C1)C4=CC=C(OCO5)C5=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sharma HA, et al. Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors. bioRxiv [Preprint]. 2025 Jan 31:2025.01.31.635883. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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