WO-459
WO-459 is a potent Gpr52 agonist. WO-459 induces dose-dependent elevation of intracellular cAMP in cells expressing Gpr52. WO-459 can be used for the research of Huntington’s disease and psychotic disorders.
For research use only. We do not sell to patients.
- CAS No.: 1313195-84-4
- Formula: C23H20F3N3O2S
- Molecular Weight:459.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
WO-459 (Compound 12) (30 min) potently activates human GPR52 expressed in CHO cells with an EC50 of 5.7 nM and an Emax of 102%[1].
WO-459 (1 pM-10 μM) potently activates human Gpr52 in HEK293/hGpr52 cells with an EC50 of 6 nM, increasing intracellular cAMP levels in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1313195-84-4
-
Molecular Weight 459.48
-
Formula C23H20F3N3O2S
-
SMILES
O=C(C1=CN(C2=CC=CC3=C2SC(CC4=CC=CC(C(F)(F)F)=C4)=C3)N=C1C)NCCO
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Nakahata T, et al. Design and synthesis of 1-(1-benzothiophen-7-yl)-1H-pyrazole, a novel series of G protein-coupled receptor 52 (GPR52) agonists. Bioorg Med Chem. 2018 May 1;26(8):1598-1608. [Content Brief]
[2]. Song H, et al. Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes. Brain. 2018;141(6):1782-1798. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WO-459 Related Classifications
HY-183945 Related Classifications
Powered by Bioz