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Cat. No.: HY-184176

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DBCO-PEG3-AP1867

DBCO-PEG3-AP1867 is a bifunctional molecular building block that binds to FKBP12^F36V, and also a SPAAC-compatible reagent suitable for synthesizing O-GlcNAcylation-targeting chimeras (OGTACs) against c-Myc. DBCO-PEG3-AP1867 is applicable to cancer-related research.

For research use only. We do not sell to patients.

Formula: C₆₅H₇₈N₄O₁₅
Molecular Weight:1155.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DBCO-PEG3-AP1867 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

DBCO-PEG3-AP1867 successfully undergoes SPAAC reaction with azide-modified c-Myc-binding oligonucleotides to form a bifunctional OGTAC construct targeting c-Myc^[1].
DBCO-PEG3-AP1867-derived OGTAC (1 μg/mL; 24 h) potently induces O-GlcNAcylation of c-Myc and the proximity interaction between c-Myc and OGT in HEK293T-fOGT cells overexpressing Flag-c-Myc^[1].
DBCO-PEG3-AP1867-derived OGTAC (0.1-5 μg/mL; 24 h) significantly reduces the viability of HeLa-fOGT cells^[1].
DBCO-PEG3-AP1867-derived OGTAC (1 μg/mL; 24 h) remodels the genomic occupancy of c-Myc and significantly downregulates MALAT1 expression in a c-Myc O-GlcNAcylation-dependent manner in HeLa-fOGT cells and HEK293T-fOGT cells overexpressing c-Myc^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1155.33
Formula C₆₅H₇₈N₄O₁₅
SMILES

COC(C=C1)=C(OC)C=C1CC[C@@H](OC([C@H]2N(C([C@@H](CC)C3=CC(OC)=C(OC)C(OC)=C3)=O)CCCC2)=O)C4=CC(OCC(NCCOCCOCCOCCNC(CCC(N5C(C=CC=C6)=C6C#CC(C=CC=C7)=C7C5)=O)=O)=O)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu T, et al. Rewiring c-Myc Transcriptional Activity with an O-GlcNAcylation Targeting Chimera (OGTAC). bioRxiv. 2026.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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