DNPH1 - 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Gene

Also Known as RCL; C6orf108; dJ330M21.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10591

About DNPH1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,225,629-43,229,481 (from NCBI)

This gene has 4 transcripts (splice variants) and 163 orthologues. Broad expression in kidney (RPKM 65.7), duodenum (RPKM 28.6) and 23 other tissues.

Summary

This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and Apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]

DNPH1 Products (2)

mRNA	Protein	Name
NM_006443.3	NP_006434.1	2'-deoxynucleoside 5'-phosphate N-hydrolase 1 isoform 1
NM_199184.2	NP_954653.1	2'-deoxynucleoside 5'-phosphate N-hydrolase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity	IDA IDA: Inferred from direct assay	25108359	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in deoxyribonucleoside monophosphate catabolic process	IDA IDA: Inferred from direct assay	25108359	GOA
involved in epithelial cell differentiation	IEP IEP: Inferred from expression pattern	21492153	GOA
involved in nucleoside salvage	IMP IMP: Inferred from mutant phenotype	33833118	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18726892	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9271375	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNPH1 Protein Structure

Nuc_deoxyrib_tr

0
100
174 a.a.

Protein Preferred Names	Protein Names
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	c-Myc-responsive protein RCL

DNPH1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DNPH1	O43598	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	DNPH1	O43598	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	DNPH1	O43598	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	DNPH1	O43598	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	DNPH1	O43598	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	DNPH1	O43598	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	DNPH1	O43598	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	DNPH1	O43598	DNPH1	Homo sapiens	O43598	Y2H Array	32296183
Intra	DNPH1	O43598	DNPH1	Homo sapiens	O43598	Y2H Pooling	16189514
Intra	DNPH1	O43598	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	DNPH1	O43598	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	DNPH1	O43598	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	DNPH1	O43598	DNPH1	Homo sapiens	O43598	Y2H Prey Pooling	32296183
Intra	DNPH1	O43598	DNPH1	Homo sapiens	O43598	Validated Y2H	32296183
Intra	DNPH1	O43598	DNPH1	Homo sapiens	O43598	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

DNPH1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86278	DNPH1 Antibody (YA5970)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Cardiomyopathy, Familial Restrictive, 1	RCM1 Restrictive Cardiomyopathy 1 Rcm Familial Restrictive Cardiomyopathy 1 Cardiomyopathy, Familial Restrictive 1 Cardiomyopathy, Restrictive, Familial, Type 1 Rcm-1
Hypotrichosis 2	HYPT2 Hypotrichosis Simplex Of The Scalp 1 Htss1 Htss Hypotrichosis, Spanish Type Spanish Type Hypotrichosis Hypotrichosis Spanish Type Hypotrichosis, Type 2 Hypotrichosis Simplex Of Scalp

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-179268	DNPH1-IN-1	Inhibitor	/	Unkown
HY-179303	DNPH1 ligand-1		/	Unkown
HY-179582	PROTAC DNPH1 Degrader 1	Degrader	/	Unkown
HY-RS03915	DNPH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19676	Dnph1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26169	Dnph1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DNPH1	RGD	RGD:620382
Felis catus	DNPH1	VGNC	VGNC:82473
Bos taurus	DNPH1	VGNC	VGNC:28149
Macaca mulatta	DNPH1	VGNC	VGNC:71877
Mus musculus	DNPH1	MGD	MGI:3039376
Canis familiaris	DNPH1	VGNC	VGNC:57238
Others	DNPH1	NCBI