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NDUFA3 - NADH:ubiquinone oxidoreductase subunit A3 Gene

Also Known as B9; CI-B9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4696

About NDUFA3

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,102,855-54,107,568 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 238 orthologues. Ubiquitous expression in kidney (RPKM 30.6), fat (RPKM 26.2) and 25 other tissues.

Summary

Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2022]

NDUFA3 Products (1)

mRNA	Protein	Name
NM_004542.4	NP_004533.1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitochondrial respiratory chain complex I assembly	IMP IMP: Inferred from mutant phenotype	27626371	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA
part of respiratory chain complex I	IDA IDA: Inferred from direct assay	12611891	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFA3 Protein Structure

NADHdh_A3

0
84 a.a.

Protein Preferred Names	Protein Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa

NDUFA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NDUFA3	O95167	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	NDUFA3	O95167	TMEM242	Homo sapiens	Q9NWH2	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	TMEM242	Homo sapiens	Q9NWH2	Y2H Array	32296183
Intra	NDUFA3	O95167	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	NDUFA3	O95167	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	NDUFA3	O95167	SLC7A8	Homo sapiens	Q9UHI5	Y2H Array	32296183
Intra	NDUFA3	O95167	SLC7A8	Homo sapiens	Q9UHI5	Validated Y2H	32296183
Intra	NDUFA3	O95167	SLC7A8	Homo sapiens	Q9UHI5	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	GOLT1A	Homo sapiens	Q6ZVE7	Validated Y2H	32296183
Intra	NDUFA3	O95167	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Array	32296183
Intra	NDUFA3	O95167	CRB3	Homo sapiens	Q9BUF7-2	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	CRB3	Homo sapiens	Q9BUF7-2	Validated Y2H	32296183
Intra	NDUFA3	O95167	CRB3	Homo sapiens	Q9BUF7-2	Y2H Array	32296183
Intra	NDUFA3	O95167	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	MUC1	Homo sapiens	P15941-11	Validated Y2H	32296183
Intra	NDUFA3	O95167	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	NDUFA3	O95167	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	NDUFA3	O95167	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	NDUFA3	O95167	TMEM101	Homo sapiens	Q96IK0	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	TMEM101	Homo sapiens	Q96IK0	Validated Y2H	32296183
Intra	NDUFA3	O95167	TMEM101	Homo sapiens	Q96IK0	Y2H Array	32296183
Intra	NDUFA3	O95167	MMGT1	Homo sapiens	Q8N4V1	Validated Y2H	32296183
Intra	NDUFA3	O95167	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	NDUFA3	O95167	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	TMEM205	Homo sapiens	Q6UW68	Validated Y2H	32296183
Intra	NDUFA3	O95167	TMEM205	Homo sapiens	Q6UW68	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	TMEM205	Homo sapiens	Q6UW68	Y2H Array	32296183
Intra	NDUFA3	O95167	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	NDUFA3	O95167	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	NDUFA3	O95167	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	NDUFA3	O95167	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	TM4SF19	Homo sapiens	Q96DZ7	Validated Y2H	32296183
Intra	NDUFA3	O95167	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	NDUFA3	O95167	LEPROTL1	Homo sapiens	O95214	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	LEPROTL1	Homo sapiens	O95214	Validated Y2H	32296183
Intra	NDUFA3	O95167	LEPROTL1	Homo sapiens	O95214	Y2H Array	32296183
Intra	NDUFA3	O95167	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	NDUFA3	O95167	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	NDUFA3	O95167	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Schizophrenia 5	SCZD5 Schizophrenia Susceptibility Locus, Chromosome 6q-Related Schizophrenia 5 With Or Without An Affective Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09128	NDUFA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NDUFA3	RGD	RGD:1588687
Mus musculus	NDUFA3	MGD	MGI:1913341
Felis catus	NDUFA3	VGNC	VGNC:81202
Others	NDUFA3	NCBI