Glutaminase
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Glutaminase (GLS) is a metabolic enzyme. Glutaminase catalyzes the conversion of glutamine to glutamate, which is a key step in glutaminolysis. The glutaminase isoenzymes GLS and GLS2 differ in their expression patterns and functional roles: GLS exhibits oncogenic properties, whereas GLS2 is regarded as a tumor suppressor. Glutaminase expression levels correlate with the degree of tumor malignancy.
For research use only. We do not sell to patients.
- CAS No.: 9001-47-2
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Glutaminase regulates glutamine metabolism, and its expression level correlates with the malignancy of tumors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
EC Number
3.5.1.2
Specific Activity
50 - 200 U/mg protein
Unit Definition
One unit is defined as the amount of enzyme that will deaminate 1.0 μmole of L-glutamine per min at pH 4.9 at 37°C
Chemical Information
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CAS No. 9001-47-2
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Appearance Solid
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Color Off-white to light yellow
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SMILES
[Glutaminase]
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Synonyms
GLS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
H2O : 1 mg/mL (Need ultrasonic and warming)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
References
[1]. Matés JM, et al. Glutaminase isoenzymes in the metabolic therapy of cancer. Biochimica et biophysica acta. Reviews on cancer. 2018 Dec;1870(2):158-164. [Content Brief]
[2]. Wang JB, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer cell. 2010 Sep 14;18(3):207-19. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glutaminase Related Classifications
HY-P2760 Related Classifications
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