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Cat. No.: HY-121839

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Manoyl oxide

Manoyl oxide is a naturally occurring labdane-type diterpene with anticancer activity. Manoyl oxide is used in cancer-related research, such as breast cancer; it also serves as an intermediate for research related to organic synthesis.

For research use only. We do not sell to patients.

CAS No.: 596-84-9
Formula: C₂₀H₃₄O
Molecular Weight:290.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Manoyl oxide Chemical Structure

CAS No.: 596-84-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC50	100 μM	Antiproliferative activity against human HCT-116 colon cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay. Antiproliferative activity against human HCT-116 colon cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay.	j.jscs.2021.101298
MCF7	IC50	50 μM	Antiproliferative activity against human MCF-7 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay. Antiproliferative activity against human MCF-7 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay.	j.jscs.2021.101298
MDA-MB-231	IC50	88 μM	Antiproliferative activity against human MDA-MB231 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay. Antiproliferative activity against human MDA-MB231 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay.	j.jscs.2021.101298
MDA-MB-468	IC50	88 μM	Antiproliferative activity against human MDA-MB468 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay. Antiproliferative activity against human MDA-MB468 breast cancer cells assessed as growth inhibition after 48 hrs incubation with manoyl oxide by MTT assay.	j.jscs.2021.101298

In Vitro

Manoyl oxide (compound 2) has an IC₅₀ value of 100 µM in HCT-116, 50 µM in MCF-7, 88 µM in MDA-MB231, and 88 µM in MDA-MB468^[1].
Manoyl oxide is detected in the leaf volatile oil of Rhododendron rufum; it is also detected in the leaf volatile oil of Rhododendron przewalskii^[2].
Manoyl oxide (compound A1) can serve as an intermediate, and its derivatives show no significant antiproliferative effect on KB, KB/VCR, K562, and K562/A02 tumor cell lines^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Breast Cancer Modeling

Chemical Information

CAS No. 596-84-9
Molecular Weight 290.48
Formula C₂₀H₃₄O
SMILES

C[C@]12CCCC(C)([C@@]1(CC[C@@]3([C@@]2(CC[C@](C=C)(O3)C)[H])C)[H])C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gani I, et al. Hemisynthesis and cytotoxic evaluation of manoyl oxide analogs from sclareol: effect of two tertiary hydroxyls & Heck coupling on cytotoxicity. Natural product research. 2025 Oct;39(19):5452-5461.

[2]. Sang YL, et al. Investigation of insecticidal activity of two Rhododendron species on stored-product insects. Journal of Plant Diseases and Protection. 2023 Apr;130(2):371-82.

[3]. Nguyen TH, et al. Further terpenoids from Vitex negundo L. growing in Vietnam. Journal of Saudi Chemical Society. 2021 Aug;25(8):101298.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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