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Cat. No.: HY-15825G

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IWP L6 (GMP)

Name: IWP L6 (GMP)
Brand: MedChemExpress
SKU: HY-15825G
Availability: PreOrder

(Synonyms: Porcn Inhibitor III (GMP))

IWP L6 (GMP) (Porcn Inhibitor III (GMP)) is IWP L6 (HY-15825) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IWP L6 (Porcn Inhibitor III) is a Porcupine (Porcn) inhibitor with an EC₅₀ of 0.5 nM. IWP L6 disrupts well-established Wnt-dependent developmental processes of embryonic and juvenile zebrafish.

For research use only. We do not sell to patients.

CAS No.: 1427782-89-5
Formula: C₂₅H₂₀N₄O₂S₂
Molecular Weight:472.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

IWP L6 (GMP) Chemical Structure

CAS No.: 1427782-89-5

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Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	0.5 nM Compound: 7; IWP-L6	Antiproliferative activity against human HeLa cell line assessed as cell growth inhibition Antiproliferative activity against human HeLa cell line assessed as cell growth inhibition	[PMID: 33822624]

In Vitro

IWP L6 (Porcn Inhibitor III) (GMP) effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP L6 (GMP) inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

IWP L6 (Porcn Inhibitor III) (GMP) is stable in human plasma over 24 h, it is rapidly metabolized in rat plasma (t_1/2 = 190 min), murine plasma (t_1/2 = 2 min), and the murine liver S9 fractions (t_1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP L6 (GMP) is highly active in zebrafish. IWP L6 exhibits more potent activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1427782-89-5
Molecular Weight 472.58
Formula C₂₅H₂₀N₄O₂S₂
SMILES

O=C(NC1=NC=C(C2=CC=CC=C2)C=C1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O
Synonyms

Porcn Inhibitor III (GMP)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang X, et al. The development of highly potent inhibitors for porcupine. J Med Chem. 2013 Mar 28;56(6):2700-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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