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Art. -Nr.: HY-122021

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J-115814

J-115814 is a potent and selective neuropeptide Y1 antagonist with K_i values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors.

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CAS. Nr.: 329716-61-2
Formel: C₂₉H₃₈ClN₅O₃S
Molecular Weight:572.16

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

J-115814 Chemical Structure

CAS. Nr.: 329716-61-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

hY₁ receptor

1.4 nM (Ki)

rNPY Y₁ receptor

1.8 nM (Ki)

mY1

1.9 nM (Ki)

hY₄ receptor

620 nM (Ki)

hY₅ receptor

6000 nM (Ki)

human Y₂ receptor

>10000 nM (Ki)

mY6

>10000 nM (Ki)

Alle Neuropeptide Y Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	1.4 nM Compound: 1	Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting	[PMID: 19487123]
HEK293	IC₅₀	0.036 μM Compound: 1	Displacement of [35S]MK499 from human ERG channel in HEK293 cells Displacement of [35S]MK499 from human ERG channel in HEK293 cells	[PMID: 19487123]

In Vivo

J-115814 (0.3, 1, 3, 10 mg/kg; i.v.) inhibits NPY-induced feeding in SD rats^[1].
J-115814 (3, 10, 30 mg/kg; i.p.) shows anorexigenic effect in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

db/db and lean C57BL6 mice^[1]
Dosage:

3, 10, 30 mg/kg
Administration:

I.p.
Result:

Decreasesd nocturnal food intake in a dose-dependent manner.

Animal Model:

SD rats^[1]
Dosage:

0.3, 1, 3, 10 mg/kg
Administration:

I.v.; 1 h before ICV NPY
Result:

Inhibited NPY-induced feeding with significant responses at 3 and 10 mg/kg.

Chemical Information

CAS. Nr. 329716-61-2
Molecular Weight 572.16
Formel C₂₉H₃₈ClN₅O₃S
SMILES

CC1=C(SC(CCC2=CC(N3CCOCC3)=CC(NC(C)C4=CC(NC(OC(C)C)=O)=CC(Cl)=C4)=N2)=N1)CC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kanatani A, et al. A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814. Mol Pharmacol. 2001 Mar;59(3):501-5. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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J-115814

Alle Neuropeptide Y Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

J-115814 Related Classifications

HY-122021 Related Classifications